Body Size at Different Ages and Risk of 6 Cancers: A Mendelian Randomization and Prospective Cohort Study-Reference-Cited by-同舟云学术

Body Size at Different Ages and Risk of 6 Cancers: A Mendelian Randomization and Prospective Cohort Study

Published:2022-04-19 Issue:9 Volume:114 Page:1296-1300
ISSN:0027-8874
Container-title:JNCI: Journal of the National Cancer Institute
language:en
Short-container-title:

Author:

Mariosa Daniela¹^ORCID,Smith-Byrne Karl¹^ORCID,Richardson Tom G²³^ORCID,Ferrari Pietro⁴^ORCID,Gunter Marc J⁴^ORCID,Papadimitriou Nikos⁴,Murphy Neil⁴^ORCID,Christakoudi Sofia⁵⁶^ORCID,Tsilidis Konstantinos K⁵⁷^ORCID,Riboli Elio⁵^ORCID,Muller David⁵^ORCID,Purdue Mark P⁸,Chanock Stephen J⁸,Hung Rayjean J⁹¹⁰,Amos Christopher I¹¹^ORCID,O’Mara Tracy A¹²,Amiano Pilar¹³¹⁴¹⁵,Pasanisi Fabrizio¹⁶,Rodriguez-Barranco Miguel¹⁷¹⁸¹⁹^ORCID,Krogh Vittorio²⁰^ORCID,Tjønneland Anne²¹²²,Halkjær Jytte²¹,Perez-Cornago Aurora²³^ORCID,Chirlaque María-Dolores¹⁹²⁴,Skeie Guri²⁵^ORCID,Rylander Charlotta²⁵,Borch Kristin Benjaminsen²⁵,Aune Dagfinn⁵²⁶²⁷²⁸^ORCID,Heath Alicia K⁵^ORCID,Ward Heather A⁵²⁹,Schulze Matthias³⁰^ORCID,Bonet Catalina³¹,Weiderpass Elisabete³²^ORCID,Davey Smith George²,Brennan Paul¹,Johansson Mattias¹^ORCID

Affiliation:

1. International Agency for Research on Cancer (IARC/WHO), Genomic Epidemiology Branch , Lyon, France

2. MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK

3. Novo Nordisk Research Centre Oxford, Oxford, UK

4. International Agency for Research on Cancer (IARC/WHO), Nutrition and Metabolism Branch , Lyon, France

5. Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London , London, UK

6. MRC Centre for Transplantation, King’s College London , London, UK

7. Department of Hygiene and Epidemiology, School of Medicine, University of Ioannina , Ioannina, Greece

8. Division of Cancer Epidemiology and Genetics, National Cancer Institute , Rockville, MD, USA

9. Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health System , Toronto, ON, Canada

10. Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto , Toronto, ON, Canada

11. Institute for Clinical and Translational Research, Baylor College of Medicine , Houston, TX, USA

12. Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute , Brisbane, Australia

13. Ministry of Health of the Basque Government, Sub Directorate for Public Health and Addictions of Gipuzkoa , San Sebastián, Spain

14. Epidemiology of Chronic and Communicable Diseases Group, Biodonostia Health Research Institute , San Sebastián, Spain

15. Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III , Madrid, Spain

16. Dipartimento di Medicina Clinica e Chirurgia, Federico II University , Naples, Italy

17. Escuela Andaluza de Salud Pública (EASP) , Granada, Spain

18. Instituto de Investigación Biosanitaria ibs.GRANADA , Granada, Spain

19. Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP) , Madrid, Spain

20. Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori , Milan, Italy

21. Danish Cancer Society Research Center , Copenhagen, Denmark

22. Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen, Denmark

23. Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford , Oxford, UK

24. Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia University , Murcia, Spain

25. Department of Community Medicine, UiT, The Arctic University of Norway , Tromsø, Norway

26. Department of Nutrition, Bjørknes University College , Oslo, Norway

27. Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital , Oslo, Norway

28. Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet , Stockholm, Sweden

29. IQVIA, Epidemiology and Outcomes Research, Real World Solutions, IQVIA , Cambridge, MA, USA

30. Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke , Nuthetal, Germany

31. Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology- IDIBELL, L’Hospitalet de Llobregat , Barcelona, Spain

32. International Agency for Research on Cancer (IARC/WHO) , Lyon, France

Abstract

Abstract It is unclear if body weight in early life affects cancer risk independently of adult body weight. To investigate this question for 6 obesity-related cancers, we performed univariable and multivariable analyses using 1) Mendelian randomization (MR) analysis and 2) longitudinal analyses in prospective cohorts. Both the MR and longitudinal analyses indicated that larger early life body size was associated with higher risk of endometrial (odds ratioMR = 1.61, 95% confidence interval = 1.23 to 2.11) and kidney (odds ratioMR = 1.40, 95% confidence interval = 1.09 to 1.80) cancer. These associations were attenuated after accounting for adult body size in both the MR and cohort analyses. Early life body mass index (BMI) was not consistently associated with the other investigated cancers. The lack of clear independent risk associations suggests that early life BMI influences endometrial and kidney cancer risk mainly through pathways that are common with adult BMI.

Funder

Cancer Research Fund (WCRF UK) and Wereld Kanker Oderzoek Fonds

World Cancer Research Fund International programme

Cancer Research UK

National Health and Medical Research Council of Australia

US National Institutes of Health

European Research Council

Wellcome Trust Centre for Human Genetics

Cancer Research UK. OncoArray genotyping of the Endometrial Cancer Association Consortium

Ovarian Cancer Association Consortium

Canadian Institutes of Health Research

Ovarian Cancer Research Fund