Why does caloric restriction increase life and healthspan? The ‘clean cupboards’ hypothesis-Reference-Cited by-同舟云学术

Why does caloric restriction increase life and healthspan? The ‘clean cupboards’ hypothesis

Published:2020-04-29 Issue:7 Volume:7 Page:1153-1156
ISSN:2095-5138
Container-title:National Science Review
language:en
Short-container-title:

Author:

Speakman John R¹²³

Affiliation:

1. State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, China

2. Institute of Biological and Environmental Sciences, University of Aberdeen, UK

3. CAS Center of Excellence in Animal Evolution and Genetics, Kunming Institute of Zoology, Chinese Academy of Sciences, China

Abstract

Summary The disposable soma hypothesis explanation of the effects of caloric restriction (CR) on lifespan fails to explain why CR generates negative impacts alongside the positive effects and does not work in all species. I propose here a novel idea called the clean cupboards hypothesis which overcomes these problems.

Funder

National Natural Science Foundation of China

Royal Society

Biotechnology and Biological Sciences Research Council

KC Wong Education Foundation

Chinese Academy of Sciences

Publisher

Oxford University Press (OUP)

Subject

Multidisciplinary

Link

http://academic.oup.com/nsr/advance-article-pdf/doi/10.1093/nsr/nwaa078/33209930/nwaa078.pdf