Engineering biocompatible TeSex nano-alloys as a versatile theranostic nanoplatform

Author:

Ling Xiang1,Jin Zhaokui2,Jiang Qi2,Wang Xiaotao1,Wei Bin3,Wang Zhongchang3,Xu Yangsen1,Cao Tianye24,Engle Jonathan W4,Cai Weibo4,Su Chenliang1,He Qianjun2

Affiliation:

1. International Collaborative Laboratory of 2D Materials for Optoelectronic Science & Technology, Engineering Technology Research Center for 2D Materials Information Functional Devices and Systems of Guangdong Province, Institute of Microscale Optoelectronics, Shenzhen University, Shenzhen 518060, China

2. Guangdong Provincial Key Laboratory of Biomedical Measurements and Ultrasound Imaging, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen 518060, China

3. Department of Quantum and Energy Materials, International Iberian Nanotechnology Laboratory (INL), Braga 4715-330, Portugal

4. Departments of Radiology and Medical Physics, University of Wisconsin-Madison, Madison, WI 53705, USA

Abstract

Abstract Photothermal nanotheranostics, especially in the near infrared II (NIR-II) region, exhibits a great potential in precision and personalized medicine, owing to high tissue penetration of NIR-II light. NIR-II-photothermal nanoplatforms with high biocompatibility as well as high photothermal effect are urgently needed but rarely reported so far. Te nanomaterials possess high absorbance to NIR-II light but also exhibit high cytotoxicity, impeding their biomedical applications. In this work, the controllable incorporation of biocompatible Se into the lattice of Te nanostructures is proposed to intrinsically tune their inherent cytotoxicity and enhance their biocompatibility, developing TeSex nano-alloys as a new kind of theranostic nanoplatform. We have uncovered that the cytotoxicity of Te nanomaterials primarily derives from irreversible oxidation stress and intracellular imbalance of organization and energy, and can be eliminated by incorporating a moderate proportion of Se (x = 0.43). We have also discovered that the as-prepared TeSex nano-alloys have extraordinarily high NIR-II-photothermal conversion efficiency (77.2%), 64Cu coordination and computed tomography contrast capabilities, enabling high-efficacy multimodal photothermal/photoacoustic/positron emission tomography/computed tomography imaging-guided NIR-II-photothermal therapy of cancer. The proposed nano-alloying strategy provides a new route to improve the biocompatibility of biomedical nanoplatforms and endow them with versatile theranostic functions.

Funder

National Natural Science Foundation of China

Development of Strategic Emerging Industries in Shenzhen

Shenzhen Basic Research Program

Shenzhen Peacock Plan

Shenzhen University

Educational Commission of Guangdong Province

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Multidisciplinary

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