Plasma and Urinary Amino Acid Profile in Children with Infantile Tremor Syndrome

Author:

Dileep Satya K1,Attri Savita Verma1,Sharawat Indar Kumar2ORCID,Vaidya Pankaj C1,Mehra Nancy1,Patial Ajay1,Sankhyan Naveen1,Singhi Pratibha D1

Affiliation:

1. Department of Pediatrics, Advanced Pediatrics Centre (APC), Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012, India

2. Department of Pediatrics, All India Institute of Medical Sciences (AIIMS), Rishikesh 249203, India

Abstract

Abstract Background Infantile Tremor Syndrome (ITS) is a disorder of infancy, and characterized by developmental delay and/or regression, pallor, skin hyperpigmentation and hypopigmented hair. It is commonly seen in infants in whom exclusive breastfeeding is given inappropriately for longer durations than recommended. ITS is predominantly reported from the Indian subcontinent and in children from a lower socioeconomic background. It is a clinical diagnosis and vitamin B12 deficiency is the most commonly accepted etiology of this entity. Objectives The primary objectives of study were to compare the plasma and urine amino acid levels among children with ITS spectrum with those of healthy children. The secondary objectives were to compare the plasma and urine amino acid levels among children with ITS and Pre-ITS. Study design This cross-sectional, observational study was carried out at a tertiary care hospital in North India. Participants A total of 50 children aged < 36 months with ITS/Pre-ITS were enrolled. Children with Pre-ITS and ITS were compared with healthy age-matched study subjects. Results Thirty-nine (78%) cases and twelve (24%) healthy children had low serum vitamin B12 levels. Folate levels were normal in all the controls, while only one case had folate deficiency. There were significant differences (p < 0.05) in the values of 32 amino acids in plasma. Among 44 urinary amino acids, levels of 30 amino acids were significantly different in the cases compared with the controls (p < 0.05). Conclusions Several changes in amino acids in the children suffering from ITS were observed. These changes may be a reflection of the metabolic derangements in ITS.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Pediatrics, Perinatology and Child Health

Reference26 articles.

1. Nutritional dystrophy and anaemia;Dikshit;Indian J Child Health,1957

2. Infantile Tremor Syndrome;Bajpai;Acta Neurol Scand,1965

3. Infantile Tremor Syndrome: a review and critical appraisal of its etiology;Goraya;J Pediatr Neurosci,2016

4. Infantile Tremor Syndrome and laryngomalacia: a novel association?;Panda;Clin Nutr ESPEN,2021

5. Infantile -tremor syndrome;Arya;Indian J Pediatr,1988

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