Corynebacterium diphtheriae Infection in Mahajanga, Madagascar: First Case Report-Reference-Cited by-同舟云学术

Corynebacterium diphtheriae Infection in Mahajanga, Madagascar: First Case Report

Published:2020-10-23 Issue:1 Volume:67 Page:
ISSN:0142-6338
Container-title:Journal of Tropical Pediatrics
language:en
Short-container-title:

Author:

Rakotomalala Rivo Solotiana¹^ORCID,Andrianirina Zo Zafitsara²,Ratsima Elisoa³,Randrianandraina Patrick⁴,Randrianirina Frédérique³,Edosoa Glenn Torrencelli⁵,Rabenandrianina Tahirimalala¹,Badell Edgar⁶⁷,Toubiana Julie⁶⁷⁸,Andrianarimanana Diavolana²,Brisse Sylvain⁶⁷,Rasamindrakotroka Andry⁹

Affiliation:

1. Laboratoire de Biologie médicale, Département de Sciences fondamentales, Centre hospitalier universitaire PZAGA, Université de Mahajanga, 401 Mahajanga, Madagascar

2. Département de Pédiatrie, Centre hospitalier universitaire PZAGA, Université de Mahajanga, 401 Mahajanga, Madagascar

3. Centre de Biologie Clinique, Institut Pasteur de Madagascar, 101 Antananarivo, Madagascar

4. Service ORL, Centre hospitalier universitaire PZAGA, Université de Mahajanga, 401 Mahajanga, Madagascar

5. Organisation Mondiale de la Santé, Bureau Pays de Madagascar, 101 Antananarivo, Madagascar

6. Institut Pasteur, National Reference Center for Corynebacteria of the Diphtheriae Complex, 75015 Paris, France

7. Institut Pasteur, Biodiversity and Epidemiology of Bacterial Pathogens, 75015 Paris, France

8. Université de Paris, General Pediatrics and Pediatric infectious diseases department, Necker-Enfants malades, APHP, 75015, Paris, France

9. Laboratoire de Formation et de Recherche en Biologie Médicale, Faculté de Médecine, Université d’Antananarivo, 101 Antananarivo, Madagascar

Abstract

Abstract Diphtheria is an infection that has been unreported for more than two decades in Mahajanga. A child, aged 4, presented with a pseudomembranous pharyngitis was associated with a dysphagia. He was from a rural municipality of Ambato Boeny at Mahajanga province and was admitted to the Pediatric Unit of the University Hospital Center. The child was not immunized against diphtheria. A throat swab was performed and cultured, from which Corynebacterium diphtheriae was identified. The strain, of biovar Mitis, was confirmed as diphtheria toxin (DT)-gene positive and produced DT (Elek test). Unfortunately, the child developed cardiac and neurological complications and died of respiratory and heart failure.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Pediatrics, Perinatology and Child Health

Link

http://academic.oup.com/tropej/article-pdf/67/1/fmaa064/36548007/fmaa064.pdf

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