G1 phase cell cycle arrest in NSCLC in response to LZ-106, an analog of enoxacin, is orchestrated through ROS overproduction in a P53-dependent manner

Author:

Yang Lin1,Zhou Jieying1,Meng Fei2,Fu Chengyu1,Zou Xiaoqian1,Liu Jinfeng1,Zhang Chengwan3,Tan Renxiang4,Li Zhiyu5,Guo Qinglong1ORCID,Wei Libin1

Affiliation:

1. State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Tongjiaxiang, Nanjing, China

2. Department of Clinical Laboratory, Jiangsu Province Hospital of Traditional Chinese Medicine, Nanjing, China

3. The Central Laboratory of Huai’an First People’s Hospital, Nanjing Medical University, Huai’an, Jiangsu Province, China

4. State Key Laboratory Cultivation Base for TCM Quality and Efficacy, Nanjing University of Chinese Medicine, Nanjing, China

5. Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Tongjiaxiang, Nanjing, China

Funder

National Natural Science Foundation of China

Natural Science Foundation of Jiangsu Province

National Science and Technology Major Project

Special Foundation for Jiangsu Overseas Visiting Scholar Program of Prominent Young Teachers and Presidents

program for construction of innovation ability in Huai’an

Open Project of State Key Laboratory Cultivation Base for TCM Quality and Efficacy

Nanjing University of Chinese Medicine

Program for Changjiang Scholars and Innovative Research Team in University

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,General Medicine

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