Downregulation of RalGTPase-activating protein promotes invasion of prostatic epithelial cells and progression from intraepithelial neoplasia to cancer during prostate carcinogenesis

Author:

Uegaki Masayuki1,Kita Yuki1,Shirakawa Ryutaro2,Teramoto Yuki3,Kamiyama Yuki1,Saito Ryoichi1,Yoshikawa Takeshi1,Sakamoto Hiromasa1,Goto Takayuki1,Akamatsu Shusuke1,Yamasaki Toshinari1,Inoue Takahiro1,Suzuki Akira4,Horiuchi Hisanori2,Ogawa Osamu1,Kobayashi Takashi1ORCID

Affiliation:

1. Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan

2. Department of Molecular and Cellular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Miyagi, Japan

3. Department of Diagnostic Pathology, Kyoto University Graduate School of Medicine, Kyoto, Japan

4. Division of Molecular and Cellular Biology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan

Funder

Ministry of Education, Culture, Sports, Science and Technology of Japan

Institute of Development, Aging and Cancer, Tohoku University

Japanese Society of Thrombosis and Hemostasis

Pfizer Academic Contribution

Sanofi

Takeda Research Support

Takeda Science Foundation

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,General Medicine

Reference45 articles.

1. Molecular genetics of prostate cancer: new prospects for old challenges;Shen;Genes Dev.,2010

2. High grade prostatic intraepithelial neoplasia (HGPIN) and prostatic adenocarcinoma between the ages of 20–69: an autopsy study of 249 cases;Sakr;In Vivo,1994

3. The frequency of latent prostatic carcinoma in young males: the Japanese experience;Shiraishi;In Vivo,1994

4. Latent prostatic carcinoma: pathological and epidemiological aspects;Yatani;Jpn. J. Clin. Oncol.,1989

5. Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer;Tomlins;Science,2005

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