Affiliation:
1. Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education , 24 Heping Road, Harbin 150040 , P. R. China
2. College of Life Science and Technology, Mudanjiang Normal University , 191 Wenhua Street, Mudanjiang 157011 , P. R. China
Abstract
Abstract
Objectives
Oligo-/polysaccharides from Cyathula officinalis Kuan (COPs) and Achyranthes bidentata Blume (ABPs) have attracted researchers’ attention in the fields of healthy food supplements and traditional Chinese medicine (Niúxī) due to their multiple bioactivities combined with their nontoxic and highly biocompatible nature. The purpose of this paper was to provide a systematic and comprehensive overview of the extraction, purification, and structural analysis methods, chemical characteristics, biological activities, and structure bioactivity relationship. Furthermore, the possible development trends and perspectives for future research, and traditional uses of Niúxī are also summarized.
Methods
All the information was gathered from a library search and scientific databases.
Key findings
Although COPs and ABPs are derived from different plants, they have similar structural features in type, structure, and glycosidic linkage patterns and biological activities in vivo and in vitro. However, there are differences in monosaccharide compositions, which can be used as an identification mark.
Conclusions
As traditional Chinese herbal medicine, C. officinalis and A. bidentata have similar pharmacological activities. The COPs and ABP possess wide pharmacological effects such as antitumor, antioxidant, anti-osteoporosis, and anti-inflammatory. Meanwhile, the biological activity and structure–activity relationship of purified COPs and ABPs are less studied, future research should focus on them.
Funder
National Key Research and Development Project of China
Applied Technology Research and Development
Heilongjiang Touyan Innovation
Heilongjiang University of Chinese Medicine
Publisher
Oxford University Press (OUP)
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