Viral Escape in the Central Nervous System with Multidrug-Resistant Human Immunodeficiency Virus-1-Reference-Cited by-同舟云学术

Viral Escape in the Central Nervous System with Multidrug-Resistant Human Immunodeficiency Virus-1

Published:2015-12-28 Issue:1 Volume:3 Page:
ISSN:2328-8957
Container-title:Open Forum Infectious Diseases
language:en
Short-container-title:

Author:

Béguelin C.¹,Vázquez M.¹,Bertschi M.²,Yerly S.³,de Jong D.²,Gutbrod K.²,Rauch A.¹,Cusini A.¹⁴

Affiliation:

1. Department of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern

2. Department of Neurology, Bern University Hospital and University of Bern

3. Laboratory of Virology, Geneva University Hospital

4. Infectious Diseases Unit, Cantonal Hospital, Chur, Switzerland

Abstract

Abstract In this study, we report the case of a patient infected with human immunodeficiency virus (HIV)-1 who developed ataxia and neurocognitive impairment due to viral escape within the central nervous system (CNS) with a multidrug-resistant HIV-1 despite long-term viral suppression in plasma. Antiretroviral therapy optimization with drugs with high CNS penetration led to viral suppression in the CSF, regression of ataxia, and improvement of neurocognitive symptoms.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

Link

http://academic.oup.com/ofid/article-pdf/3/1/ofv210/33600687/ofv210.pdf

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