Comparison of 2 Fillers for Lip Injection—A Randomized-Controlled Clinical Trial Assessed by 3D Imaging

Abstract

Abstract Background Lip aging is a concern for many, and hyaluronic acid (HA) injections are a popular solution. Objectives This study compared 2 different HA gel technologies (OBT and NASHA) for lip augmentation in 20 volunteers. Methods Both groups received treatment from the same injector using the same method. Lip volume was measured with a 3D stereophotogrammetry device before, immediately after, and 30 days posttreatment. Patient satisfaction and adverse events were assessed through FACE-Q scales analysis. Results The NASHA group showed an immediate volume increase (P = .01), which decreased after 30 days. The OBT group did not show a significant immediate growth (P = .535) but did exhibit a significant increase after 30 days (P = .014). After 30 days, there were no significant volume differences between the groups (P = .802 and P = .999). FACE-Q analysis revealed no significant differences among groups after 30 days. Conclusions This study highlights that less cohesive gels may modify faster in dynamic lip areas, emphasizing the importance of selecting products based on their physicochemical and rheological properties. In the context of lip augmentation with HA, it is important not to consider immediate aesthetic changes as definitive results, as volume changes may persist and develop over time after the treatment. Level of Evidence: 2