Several structural motifs cooperate in determining the highly effective anti-thrombin activity of NU172 aptamer-Reference-Cited by-同舟云学术

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Several structural motifs cooperate in determining the highly effective anti-thrombin activity of NU172 aptamer

Published:2018-10-24 Issue:22 Volume:46 Page:12177-12185
ISSN:0305-1048
Container-title:Nucleic Acids Research
language:en
Short-container-title:

Author:

Troisi Romualdo¹,Napolitano Valeria¹,Spiridonova Vera²,Russo Krauss Irene¹³,Sica Filomena¹^ORCID

Affiliation:

1. Department of Chemical Sciences, University of Naples ‘Federico II’, Naples 80126, Italy

2. A.N. Belozersky Institute of Physico-Chemical Biology, M.V. Lomonosov Moscow State University, Moscow 119992, Russia

3. CSGI – Consorzio Interuniversitario per lo Sviluppo dei Sistemi a Grande Interfase, Sesto Fiorentino, FI 50019, Italy

Publisher

Oxford University Press (OUP)

Subject

Genetics

Link

http://academic.oup.com/nar/article-pdf/46/22/12177/27179301/gky990.pdf

Reference52 articles.

1. Global burden of thrombosis: epidemiologic aspects;Wendelboe;Circ. Res.,2016

2. The state of US Health, 1990–2016: burden of diseases, injuries, and risk factors among US states;Collaborators, U.S.B.o.D.;JAMA,2018

3. Modulation of the coagulation cascade using aptamers;Woodruff;Arterioscler. Thromb. Vasc. Biol.,2015

4. The central role of thrombin in hemostasis;Crawley;J. Thromb. Haemostasis,2007

5. First-in-human experience of an antidote-controlled anticoagulant using RNA aptamer technology: a phase 1a pharmacodynamic evaluation of a drug-antidote pair for the controlled regulation of factor IXa activity;Dyke;Circulation,2006

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