Thermodynamic stability and Watson–Crick base pairing in the seed duplex are major determinants of the efficiency of the siRNA-based off-target effect-Reference-Cited by-同舟云学术

Thermodynamic stability and Watson–Crick base pairing in the seed duplex are major determinants of the efficiency of the siRNA-based off-target effect

Published:2008-11-06 Issue:22 Volume:36 Page:7100-7109
ISSN:1362-4962
Container-title:Nucleic Acids Research
language:en
Short-container-title:

Author:

Ui-Tei Kumiko,Naito Yuki,Nishi Kenji,Juni Aya,Saigo Kaoru

Publisher

Oxford University Press (OUP)

Subject

Genetics

Link

http://academic.oup.com/nar/article-pdf/36/22/7100/16750666/gkn902.pdf

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3. siRNA-mediated off-target gene silencing triggered by a 7 nt complementation;Lin;Nucleic Acids Res.,2005

4. Widespread siRNA “off-target” transcript silencing mediated by seed region sequence complementarity;Jackson;RNA,2006

5. 3′ UTR seed matches, but not overall identity, are associated with RNAi off-targets;Birmingham;Nat. Methods,2006

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