Evaluation of the effectiveness of alginate-based hydrogels in preventing peritoneal adhesions

Author:

Meng Zhu1,Wang Han12,Liu Yu13,Yang Minyi1,Zeng Hang14,Han Qianqian1

Affiliation:

1. National Institutes for Food and Drug Control , People’s Republic of China

2. School of Materials Science and Engineering, Beijing Institute of Technology , People’s Republic of China

3. YanTai University , People’s Republic of China

4. China Pharmaceutical University , People’s Republic of China

Abstract

AbstractInfertility and intestinal blockage are just two examples of the postoperative consequences that can arise from peritoneal damage, which can also result in severe peritoneal fibrosis and peritoneal adhesions. Peritoneal adhesions are still not effectively treated, and both pharmaceutical therapy and biomaterial barriers have only had modest preventative effects. In this work, we looked into the effectiveness of in-place injectable sodium alginate hydrogel for peritoneal adhesion prevention. The findings demonstrated that sodium alginate hydrogel promoted human peritoneal mesothelial cell proliferation and migration, prevented peritoneal fibrosis by suppressing the production of transforming growth factor-β1, and, most importantly, promoted mesothelium self-repair. These findings imply that this brand-new sodium alginate hydrogel is a good candidate material for peritoneal adhesion prevention.

Funder

National Key R&D Program of China

Publisher

Oxford University Press (OUP)

Subject

Biomaterials

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