Effects of Morphine Analgesia in Ventilated Preterm Neonates-Reference-Cited by-同舟云学术

Effects of Morphine Analgesia in Ventilated Preterm Neonates

Published:2024-09 Issue: Volume: Page:241-245
ISSN:
Container-title:50 Studies Every Neonatologist Should Know
language:en
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Author:

Mitra Souvik

Abstract

Abstract Morphine infusion for pain control in ventilated preterm neonates is postulated to reduce neurological injury. A large, multicenter, blinded randomized controlled trial (RCT), NEOPAIN investigated whether preemptive (prophylactic) morphine analgesia, as compared with placebo, reduced early neurological injury in 898 ventilated preterm neonates. There was no difference in the primary composite outcome of neonatal death, severe intraventricular hemorrhage (IVH), or periventricular leukomalacia (PVL) between placebo and morphine groups (26% versus 27%). Post-hoc secondary analysis evaluated differences between enrolled infants who received open-label morphine and those who did not. This revealed worse outcomes among infants receiving open-label morphine.

Publisher

Oxford University PressNew York

Reference7 articles.

1. Effects of morphine analgesia in ventilated preterm neonates: primary outcomes from the NEOPAIN randomised trial.;Lancet

2. Consensus statement for the prevention and management of pain in the newborn.;Adolesc Med,2001

3. Analgesia and sedation in preterm neonates who require ventilatory support: results from the NOPAIN trial. Neonatal Outcome and Prolonged Analgesia in Neonates.;Arch Pediatr Adolesc Med

4. An introduction to multiplicity issues in clinical trials: the what, why, when and how.;Int J Epidemiol

5. Analysis of clinical trials by treatment actually received: is it really an option?;Stat Med