The World Health Organization (WHO)—a specialized agency of the United Nations (UN)—is a global organization that stimulates international action on global health issues, with the ultimate goal of having the highest possible level of health attained by all people. In 1993, the UN and WHO International Expert Meeting on Guidelines for the Formulation and Implementation of Comprehensive National Strategies for the Prevention of Suicidal Behaviour was held, which resulted in a set of guidelines that encourage national suicide prevention strategies. Moreover, suicide prevention became a global health priority and was integrated into the WHO Mental Health Action Plan 2013–2020. This text will discuss the WHO’s key roles in suicide prevention, such as: establishing international and interdisciplinary partnerships; collecting, compiling, and disseminating essential information; providing sound, clear, and reliable guidance; and establishing effective, cost-effective, and innovative services for suicide prevention.