Effect of Albumin on Serum Digoxin Radioimmunoassays

Author:

Voshall David L1,Hunter Lynda1,Grady Harold J1

Affiliation:

1. Pathology Department, Baptist Memorial Hospital, 6601 Rockhill Road, Kansas City, Mo. 64131

Abstract

Abstract The use of certain commercially available radioimmunoassay kits for measurement of digoxin results in errors in the determined digoxin concentration of patients when these kits are used according to manufacturers' directions. One factor that is, in part, responsible for these errors is a difference between standards and samples with respect to albumin concentration. Three of the four kits investigated showed a significant inverse relationship between the albumin concentration in the sample and the binding of radiolabeled digoxin by its antibody when the albumin concentration was varied over an extended range. It is apparent, however, that differences in albumin concentration do not completely explain the observed variations in the assay values.

Publisher

Oxford University Press (OUP)

Subject

Biochemistry, medical,Clinical Biochemistry

Cited by 16 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Inter and Intra Laboratory Variation of Digoxin Radioimmunoassay in Sweden;Acta Pharmacologica et Toxicologica;2009-03-13

2. Problems with the immunoassay of digoxin;Journal of Pharmaceutical and Biomedical Analysis;1987-01

3. Selective Antibody Responsive Membrane Electrodes;Electrochemical Sensors in Immunological Analysis;1987

4. The Role of Immunoassay in the Clinical Laboratory;Progress in Clinical Biochemistry and Medicine;1986

5. Interference in Immunoassay;CRC Critical Reviews in Clinical Laboratory Sciences;1984-01

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