Cross reactivity of digitoxin and spironolactone in two radioimmunoassays for serum digoxin.

Author:

Müller H,Bräuer H,Resch B

Abstract

Abstract We measured the cross reactivity of two medications--digitoxin and spironolactone--in two digoxin radioimmunoassay (liquid and solid-phase) kit procedures. Both tests showed similar average percentages of cross reactivity with digitoxin (7.2 and 8.9% for intravenous, and 11.9 and 10.9% for oral administration), but no cross reactivity with spironolactone or its metabolites after equal intravenous or oral doses.

Publisher

Oxford University Press (OUP)

Subject

Biochemistry, medical,Clinical Biochemistry

Cited by 7 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Radioimmunoassay of Drugs in Body Fluids in a Forensic Context;Forensic Science Progress;1988

2. Problems with the immunoassay of digoxin;Journal of Pharmaceutical and Biomedical Analysis;1987-01

3. Drug level monitoring: cardiovascular drugs;Journal of Chromatography B: Biomedical Sciences and Applications;1985-05

4. Determination of digitalis-glycosides by HPLC and reaction-detection;Fresenius' Zeitschrift für analytische Chemie;1985-01

5. Cardiac Glycosides;Studies in Analytical Chemistry;1983

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