Affiliation:
1. Division of Biochemistry and Department of Nephrology, Walter Reed Army Institute of Research, Washington, D. C. 20012
Abstract
Abstract
We describe a simple, rapid fluorometric assay for separate quantitative analysis of procainamide and N-acetylprocainamide in mixtures. The effective linear range (fluorescence vs. concentration) in serum is 0.1 to 10.0 mg/liter, regardless of the ratio (by weight) of the two drugs from 1:10 to 10:1. Analytical recoveries by the extraction method used were 100.0 ± 3.0% and 98.0 ± 4.0%, respectively. For determination of either compound, the maximum coefficient of variation was 10%.
Publisher
Oxford University Press (OUP)
Subject
Biochemistry (medical),Clinical Biochemistry
Cited by
15 articles.
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