Affiliation:
1. Sections of Biochemistry and Endocrinology, Scott and White Clinic, Temple, Tex. 76501
Abstract
Abstract
A direct colorimetric method is described for the determination of propylthiouracil in serum, which is based on reaction of the drug at pH 8.0 with 2,6-dichloroquinone-chloroimide to produce a colored chloroform-soluble compound. After isolation from the aqueous layer with phase-separating filter paper, the chloroform solution is read against a chloroform blank at 435 nm. Propylthiouracil added to drug-free serum serves as a control sample. The method obeys Beer's law up to a concentration of at least 10 mg/liter.
Publisher
Oxford University Press (OUP)
Subject
Biochemistry, medical,Clinical Biochemistry
Cited by
24 articles.
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