An Automated Method for the Determination of Sulfonamides in Plasma-Reference-Cited by-同舟云学术

An Automated Method for the Determination of Sulfonamides in Plasma

Published:1965-12-01 Issue:12 Volume:11 Page:1045-1050
ISSN:0009-9147
Container-title:Clinical Chemistry
language:en
Short-container-title:

Author:

Falk H B¹,Kelly R G¹

Affiliation:

1. Department of Pharmacological Research, Lederle Laboratories, American Cyanamid Company, Pearl River, N. Y. 10965

Abstract

Abstract An automated adaptation of the Bratton-Marshall procedure for sulfonamides has been developed. As sulfonamides exhibit varying degrees of protein binding, application of the method to plasma is dependent upon release of these compounds prior to automated dialysis. This release is effected by the acidification of the sample. The results obtained with and without this preliminary acidification are discussed.

Publisher

Oxford University Press (OUP)

Subject

Biochemistry (medical),Clinical Biochemistry

Link

http://academic.oup.com/clinchem/article-pdf/11/12/1045/32818332/clinchem1045.pdf

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