Affiliation:
1. Battelle, Columbus Laboratories, 505 King Ave., Columbus, Ohio 43201
Abstract
Abstract
A highly sensitive and specific method is described for quantitative determination of morphine in urine. Used in the method is a gas chromatograph and a computerized, quadrupole mass spectrometer operated under chemical ionization conditions. Morphine concentrations as low as 5 ng/ml can be measured by selected ion monitoring, with N-trideuteromethyl morphine as the internal standard. The sensitivity and specificity of the method is illustrated by the detection and quantitation of morphine in urine after ingestion of cough medicine containing codeine.
Publisher
Oxford University Press (OUP)
Subject
Biochemistry, medical,Clinical Biochemistry
Cited by
30 articles.
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1. Determination of Morphine in Urine;Applications of Ion Exchange Materials in Biomedical Industries;2019
2. Clinical Toxicology;Tietz Textbook of Clinical Chemistry and Molecular Diagnostics;2012
3. Immunoassay of Drugs;Ciba Foundation Symposium 26 - The Poisoned Patient: The Role of the Laboratory;2008-05-30
4. Analysis of Morphine and Related Analgesics by Gas Phase Methods;Methods of Biochemical Analysis;2006-10-31
5. Gas chromatographic-mass spectrometric procedures used for the identification and determination of morphine, codeine and 6-monoacetylmorphine;Journal of Chromatography A;1994-07