Clinical outcomes, pharmacological treatment, and quality of life of patients with stable coronary artery diseases managed by cardiologists: 1-year results of the START study
Author:
De Luca Leonardo1, Temporelli Pier Luigi2, Riccio Carmine3, Gonzini Lucio4, Marinacci Lina5, Tartaglione Sara Norma6, Costa Paolo7, Scherillo Marino8, Senni Michele9, Colivicchi Furio10, Gulizia Michele Massimo11, De Luca L, Temporelli P L, Riccio C, Colivicchi F, Amico A F, Formigli D, Geraci G, Di Lenarda A, Gulizia M M, De Luca L, Maggioni A P, Lucci D, Maggioni A P, Lucci D, Lorimer A, Orsini G, Gonzini L, Fabbri G, Priami P, Maras P, Ramani F, Falcone C, Passarelli I, Mauri S, Calabrò P, Bianchi R, Di Palma G, Anna S, Sebastiano S, Mascia F, Vetrano A, Fusco A, Proia E, Colivicchi F, Aiello A, Tomai F, Licitra R, Petrolini A, Bosco B, Fazzi V, Magliari F, Callerame M, Mazzella T, Lettica G V, Coco G, Incao F, Marinacci L, D'Addario S, Tartaglione S N, Ubaldi S, Sanchez F A, Costa P, Manca G, Failla M, Scherillo M, Procaccini V, Formigli D, Senni M, Luminita E M, Bonomo P, Mossa C, Corda S, Colavita A R, Trevisonno G, Vizzari G, Cosentino N, Formaro C, Paolillo C, Nalin I L, De Rosa F M, Fontana F, Fuscaldo G F, Passamonti E, Bertella E, Calvaruso E V, Varani E, Tani F, Cicchitelli G, Gabrielli D, Paoloni P, Marziali A, Campo G, Tebaldi M, Biscaglia S, Di Biase M, Brunetti N D, Gallotta A M, Mattei L, Marini R, Balsemin F, D'Urbano M, Naio R, Vicinelli P, Arena G, Mazzini M, Gigli N, Miserrafiti B, Monopoli A, Mortara A, Delfino P, Chioffi M M, Marino P, Gravellone M, Barbieri L, Ledda A, Geraci G, Carmina M G, Raisaro A E, Di Giacomo C, Somaschini A, Fasano M L, Sannazzaro M, Arcieri R, Pantaleoni M, Leuzzi C, Gorlato G, Greco G, Chiera A, Ammaturo T A, Malanchini G, Corral M P Del, Tedesco L, Pede S, Urso L G, Piscione F, Galasso G, Provasoli S, Fattore L, Lucca G, Cresti A, Anna S, Sebastiano S, Cardillo A, Fera M S, Vennettilli F, Gaudio C, Paravati V, Caldarola P, Locuratolo N, Verlato R, De Conti F, Turiano G, Preti G, Moretti L, Silenzi S, Fazzi V, Colonna G, Picciolo A, Nicosia A, Cascone C, Di Sciascio G, Mangiacapra F, Russo A, Villella M, Esposito G, Cosmi F, D'Orazio S, Costantini C, Lanari A, De Rosa P, Esposito L, Bilato C, Valle C Dalla, Ceresa M, Colombo E, Pennisi V, Casciola G, Driussi M, Bisceglia T, Scalvini S, Rivadossi F, Volpe M, Comito F, Scorzoni D, Grimoldi P, Lagioia R, Santoro D, De Cesare N, Comotti T, Poli A, Martina P, Musolino M F, Multari E I, Bilardo G, Scalchi G, Olivieri C, Caranci F, Pavan D, Ganci G, Mariani A, Falchetti E, Lanzillo T, Caccavale A, Bongo A S, Rizzi A, Favilli R, Maffei S, Mallardo M, Fulgione C, Bordin F, Bonmassari R, Battaia E, Puzzo A, Vianello G, D'Arpino A, Romei M, Pajes G, Petronzelli S, Ghezzi F, Brigido S, Pignatelli L, Brscic E, Sori P, Russo M, Biancolillo E, Ignone G, De Giorgio N A, Campaniello C, Ponticelli P, Margonato A, Gerosa S, Cutaia A, Casalicchio C, Bartolomucci F, Larosa C, Spadafina T, Putignano A, De Cristofaro R, Bernardi L, Sommariva L, Celestini A, Bertucci C M, Marchetti M, Grisolia E Franceschini, Ammendolea C, Carini M, Scipione P, Politano M, Rubino G, Reina C, Peccerillo N, Paloscia L, D'Alleva A, Petacchi R, Pignalosa M, Lucchetti D, Di Palma F, Mastra R A La, Amico A F, De Filippis M, Fontanella B, Zanini G, Casolo G, Meglio J Del, Parato V M, Genovesi E, D'Alimonte A, Miglioranza A, Alessandri N, Moscariello F, Mauro C, Sasso A, Caso P, Petrillo C, Napoletano C, Paparoni S R, Bernardo V, Serdoz R, Rotunno R, Oppo I, Aloisio A, Aurelio A, Licciardello G, Cassaniti L, Gulizia M M, Francese G M, Marcassa C, Temporelli P L, Villani R, Zorzoli F, Mileto F, De Vecchis M, Amico A F, Scolozzi D, Lupi G, Caruso D, Rebulla E, Fata B La, Anselmi M, Girardi P, Borruso E, Ferrantelli G, Sassone B, Bressan S, Capriolo M, Pelissero E, Piancastelli M, Gobbi M, Cocco F, Bruno M G, Berti S, Surdo G Lo, Tanzi P, De Rosa R, Vilei E, De Iaco M R, Grassi G, Zanella C, Marullo L, Alfano G, Pelaggi P, Talarico R, Tuccillo B, Irace L, Di Lorenzo L, Zarrilli A, Bongini M, Ranise A, Aprile A, Fornengo C, Capogrosso V, Tranghese A, Golia B, Marziano A, Roncon L, Picariello C, Bagni E, Leci E, Gregorio G, Gatto F, Piemonte F, Puzio E, Navazio A, Guerri E, Belmonte E, Marino F, Di Belardino N, Di Nuzzo M R, Epifani M, Comolatti G, Conconi B, Benea D, Casu G, Merella P, Ammirati M A, Corrado V M, Spagnolo D, Caico S I, Bonizzato S, Margheri M, Corrado L, Antonicelli R, Ferrigno C, Merlino A, Nassiacos D, Antonelli A, Marchese A, Uguccioni M, Villella A, Navazio A, Bechi S, Bianco F Lo, Bedogni F, Negro L, Donato L, Statile D, Cassin M, Fedele F, Granatelli A, Calcagno S, Politi A, Serdoz R, Pani A,
Affiliation:
1. Division of Cardiology, Interventional Cardiology Unit, S. Giovanni Evangelista Hospital, Via Parrozzani, 3 Tivoli, Rome, Italy 2. Division of Cardiology, Istituti Clinici Scientifici Maugeri, IRCCS, Veruno, Via Revislate, 13, Novara, Italy 3. Division of Cardiology, Azienda Ospedaliera Sant'Anna e San Sebastiano, Via F. Palasciano, Caserta, Italy 4. ANMCO Research Center, Via A. la Marmora, 36, Firenze, Italy 5. Division of Cardiology, Presidio Ospedaliero Città di Castello, Via L. Angelini, 10, Perugia, Italy 6. Division of Cardiology, Presidio Ospedaliero of Sanremo, Via Giovanni Borea, 56, Imperia, Italy 7. Division of Cardiology, G Di Maria Hospital, Avola, Vi G Mazzini, Siracusa, Italy 8. Division of Cardiology, Azienda Ospedaliera G. Rummo, Via Pacevecchia, 53, Benevento, Italy 9. Division of Cardiology, ASST Papa Giovanni XXIII, Piazza OMS, 1, Bergamo, Italy 10. Division of Cardiology, S. Filippo Neri Hospital, Via Giovanni Martinotti, 20, Rome, Italy 11. Division of Cardiology, Garibaldi-Nesima Hospital, Via Palermo, 636, Catania, Italy
Abstract
Abstract
Aims
We evaluated the 1-year clinical events, pharmacological management, and quality of life in a contemporary cohort of stable coronary artery disease (CAD) patients managed by cardiologists.
Methods and results
START (STable Coronary Artery Diseases RegisTry) was a prospective, observational, nationwide study that enrolled 5070 stable CAD patients over 3 months in 183 cardiology centres in Italy. At 1 year, 4790 (94.5%) patients had data on vital status. Death occurred in 107 (2.2%) patients and the cause of death was cardiovascular in 41 (38.3%) of cases. Among the 4775 patients with follow-up data on clinical events available, a hospitalization due to cardiovascular and non-cardiovascular causes occurred in 523 (11.0%) and in 231 (4.8%) of cases, respectively. Over 60% of patients reported as ‘no problems’ in all domains (61.4–84.5%) of the EuroQoL quality of life 5D-5L questionnaire. Among the 3239 patients with clinical visit/telephone interview at follow-up, in whom optimal medical therapy (OMT; aspirin or thienopyridine, β-blocker, and statin) was prescribed at enrolment, 2971 (91.7%) were still receiving OMT at follow-up. At multivariable analysis, only increasing age (odds ratio 0.98; 95% confidence interval 0.97–0.99; P = 0.04) resulted as independent negative predictor of OMT persistence at 1 year from enrolment.
Conclusion
In this large, contemporary registry, stable CAD patients managed by cardiologists presented a high rate of clinical events at 1 year. Nevertheless, the persistence to OMT and quality of life appeared reasonable.
Funder
Heart Care Foundation ANMCO Research Centre Heart Care Foundation Menarini
Publisher
Oxford University Press (OUP)
Subject
Cardiology and Cardiovascular Medicine,Health Policy
Cited by
17 articles.
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