The Human Predicament engages life’s big questions. Are our lives meaningless? Is death bad? Would immortality be better? Alternatively, should we hasten our deaths by acts of suicide? Many people are tempted to offer comforting, optimistic answers to these existential questions. The Human Predicament offers a less sanguine assessment and defends a substantial, but not unmitigated, pessimism. It is argued that while our lives can have some meaning, we are ultimately the insignificant beings that we fear we are. There is no point to human life as a whole, and individual human lives have no cosmic purpose. Nor is meaning the only way in which our lives are deficient. A candid appraisal reveals that the quality of life, although less bad for some people than for others, leaves much to be desired in even the best cases. Death, however, is not generally the solution. It exacerbates rather than mitigates our cosmic meaninglessness. It can release us from suffering but even when it does, it imposes another cost—annihilation. The human predicament is thus forged by both life and death. This unfortunate state of affairs has nuanced implications for how we should think about immortality and suicide, which are also discussed in The Human Predicament.