Unraveling the molecular mechanism of the interaction between cyclodextrin-based nanoparticles (CDNPs) and paroxetine hydrochloride

Abstract

Abstract Cyclodextrin-based nanoparticles (CDNPs) have shown promise as versatile carriers for improving drug delivery systems. This study investigates the binding constants governing the interaction between paroxetine hydrochloride (PRX) and β-cyclodextrin (βCD) and β-cyclodextrin epichlorohydrin polymer (βCDNP), utilizing a range of methodologies. The findings demonstrate enhanced binding affinity between PRX and βCDNP, offering insights into the binding behavior. Furthermore, the presence of a 2:1 βCD-PRX inclusion complex within the polymer suggests potential applications in drug delivery, particularly for improving solubility and stability of poorly water-soluble drugs. These results contribute to our understanding of host-guest interactions, with implications for enhancing therapeutic efficacy and patient outcomes. The study offers valuable insights into supramolecular chemistry and pharmaceutical sciences, paving the way for more effective drug delivery systems.