Functional Synthetic Biology

Author:

Aldulijan Ibrahim1ORCID,Beal Jacob2ORCID,Billerbeck Sonja3ORCID,Bouffard Jeff4ORCID,Chambonnier Gaël5ORCID,Ntelkis Nikolaos6ORCID,Guerreiro Isaac7,Holub Martin8ORCID,Ross Paul9,Selvarajah Vinoo7,Sprent Noah10ORCID,Vidal Gonzalo11ORCID,Vignoni Alejandro12ORCID

Affiliation:

1. Systems Engineering, Stevens Institute of Technology , 1 Castle Point Terrace, Hoboken, 07030, NJ, USA

2. Intelligent Software & Systems, Raytheon BBN Technologies , 10 Moulton Street, Cambridge, 02138, MA, USA

3. Molecular Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen , Nijenborgh 7, 9747 AG, Groningen, The Netherlands

4. Centre for Applied Synthetic Biology, and Department of Biology, Concordia University , 7141 Sherbrooke Street West, Montréal, H4B 1R6, Québec, Canada

5. Department of Biological Engineering, Massachusetts Institute of Technology , Cambridge, 02139, MA, USA

6. Specialized Metabolism research group, Center for Plant Systems Biology, VIB-Ghent University , Technologiepark 71, Zwijnaarde, 9052, Belgium

7. iGEM Foundation, 45 Prospect Street, Cambridge, 02139, MA, USA

8. Delft University of Technology, Van der Maasweg 9, 2629 HZ, The Netherlands

9. BioStrat Marketing, 9965 Harbour Lake Circle, Boynton Beach, FL, 33437, USA

10. Department of Chemical Engineering, Imperial College London , South Kensington Campus, Exhibition Road, SW7 2AZ, UK

11. Interdisciplinary Computing and Complex BioSystems (ICOS) research group, School of Computing, Newcastle University , Devonshire Building, Devonshire Terrace, NE1 7RU, Newcastle Upon Tyne, UK

12. Synthetic Biology and Biosystems Control Lab, Instituto de Automatica e Informatica Industrial, Universitat Politecnica de Valencia , Camino de Vera s/n, 46022, Valencia, Spain

Abstract

AbstractSynthetic biologists have made great progress over the past decade in developing methods for modular assembly of genetic sequences and in engineering biological systems with a wide variety of functions in various contexts and organisms. However, current paradigms in the field entangle sequence and functionality in a manner that makes abstraction difficult, reduces engineering flexibility and impairs predictability and design reuse. Functional Synthetic Biology aims to overcome these impediments by focusing the design of biological systems on function, rather than on sequence. This reorientation will decouple the engineering of biological devices from the specifics of how those devices are put to use, requiring both conceptual and organizational change, as well as supporting software tooling. Realizing this vision of Functional Synthetic Biology will allow more flexibility in how devices are used, more opportunity for reuse of devices and data, improvements in predictability and reductions in technical risk and cost.

Publisher

Oxford University Press (OUP)

Subject

Agricultural and Biological Sciences (miscellaneous),Biomedical Engineering,Biomaterials,Bioengineering,Biotechnology

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