Dog10K: an international sequencing effort to advance studies of canine domestication, phenotypes and health

Author:

Ostrander Elaine A1,Wang Guo-Dong23,Larson Greger4,vonHoldt Bridgett M5ORCID,Davis Brian W6,Jagannathan Vidhya7,Hitte Christophe8,Wayne Robert K9,Zhang Ya-Ping2,André Catherine10,Axelsson Erik11,Boyko Adam12,Davis Brian W13,Forman Oliver14,Frantz Laurent15,Hitte Christophe16,Jagannathan Vidhya17,Karlsson Elinor18,Kidd Jeffrey19,Larson Greger20,Leeb Tosso17,Lindblad-Toh Kerstin21,Lohi Hannes22,Lohmueller Kirk E23,Marques-Bonet Tomas24,Mellersh Catherine25,Ostrander *Elaine A26,Savolainen Peter27,Schnabel Robert28,vonHoldt Bridgett M29,Wang *Guo-Dong2,Wayne *Robert K23,Yang Ziheng30,Zhai Weiwei31,Zhang *Ya-Ping2,

Affiliation:

1. National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA

2. State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China

3. Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming 650223, China

4. Palaeogenomics and Bio-Archaeology Research Network, School of Archaeology, University of Oxford, Oxford OX1 3TG, UK

5. Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544-1014, USA

6. College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77840, USA

7. Institute of Genetics, Vetsuisse Faculty, University of Bern, Bern CH-3001, Switzerland

8. IGDR, CNRS, University of Rennes, Rennes F-3500, France

9. Department of Ecology and Evolutionary Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA

10. University of Rennes, CNRS, IGDR, UMR6290 - F-3500 Rennes, France

11. Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala biomedicinska centrum BMC, Husarg. 3 75237 Uppsala, Sweden

12. Department of Biomedical Sciences, Cornell University College of Veterinary Medicine, Veterinary Research Tower T8016A, Box 17, Ithaca, NY 14853, USA

13. College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA

14. Genetics Research Unit, Mars Inc., Cambridge, UK

15. School of Biological and Chemical Sciences, Queen Mary University of London, London, UK

16. University of Rennes, CNRS, IGDR - UMR6290, F-3500 Rennes, France

17. Institute of Genetics, Vetsuisse Faculty, University of Bern, Bern, Switzerland

18. Bioinformatics and Integrative Biology at University of Massachusetts Medical School, and Vertebrate Genomics and Genetics Group at the Broad Institute of the Massachusetts Institute of Technology and Harvard, Boston, MA, USA

19. Departments of Human Genetics and Computational Medicine and Bioinformatics, University of Michigan Medical School, 3726A Med Sci II, Ann Arbor, MI 48109, USA

20. Research Laboratory for Archaeology and the History of Art, Dysons Perrins Building, South Parks Road, University of Oxford, Oxford, OX1 3QY, UK

21. Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden and Broad Institute of the Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA

22. Research Programs Unit, Molecular Neurology and Department of Veterinary Biosciences, University of Helsinki and Folkhälsan Institute of Genetics, PO Box 63, Helsinki, Finland

23. Ecology and Evolutionary Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA

24. Institut Biologia Evolutiva (Universitat Pompeu Fabra/CSIC) ICREA, Barcelona, Spain

25. Animal Health Trust, Lanwades Park, Kentford, Newmarket, Suffolk, CB8 7UU, UK

26. Room 5351, Building 50, National Human Genome Research Institute, National Institutes of Health, 50 South Drive, Bethesda, MD 20892, USA

27. School of Biotechnology, Science for Life Laboratory, Royal Institute of Technology in Stockholm, PO Box 1031, SE-171 21, Solna, Sweden

28. Division of Animal Sciences, Informatics Institute, University of Missouri-Columbia, Columbia, MO 65211, USA

29. Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA

30. Department of Genetics, University College London, London, WC1E 6BT, UK

31. Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, P.R. China

Abstract

ABSTRACT Dogs are the most phenotypically diverse mammalian species, and they possess more known heritable disorders than any other non-human mammal. Efforts to catalog and characterize genetic variation across well-chosen populations of canines are necessary to advance our understanding of their evolutionary history and genetic architecture. To date, no organized effort has been undertaken to sequence the world's canid populations. The Dog10K Consortium (http://www.dog10kgenomes.org) is an international collaboration of researchers from across the globe who will generate 20× whole genomes from 10 000 canids in 5 years. This effort will capture the genetic diversity that underlies the phenotypic and geographical variability of modern canids worldwide. Breeds, village dogs, niche populations and extended pedigrees are currently being sequenced, and de novo assemblies of multiple canids are being constructed. This unprecedented dataset will address the genetic underpinnings of domestication, breed formation, aging, behavior and morphological variation. More generally, this effort will advance our understanding of human and canine health.

Funder

Chinese Academy of Sciences

National Natural Science Foundation of China

National Institutes of Health

Swedish Research Council

European Research Council

Natural Environmental Research Council

French Tissue Bank

Young Innovation Promotion Association

Publisher

Oxford University Press (OUP)

Subject

Multidisciplinary

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