Magnetic Resonance Imaging Studies in Duchenne Muscular Dystrophy: Linking Findings to the Physical Therapy Clinic

Author:

Senesac Claudia R1,Barnard Alison M2,Lott Donovan J3,Nair Kavya S3,Harrington Ann T4,Willcocks Rebecca J3,Zilke Kirsten L5,Rooney William D6,Walter Glenn A2,Vandenborne Krista3

Affiliation:

1. Department of Physical Therapy, University of Florida, Box 100154, UFHSC, Gainesville, FL 32610-0154 (USA)

2. Department of Physiology and Functional Genomics, University of Florida

3. Department of Physical Therapy, University of Florida

4. Center for Rehabilitation, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania; and Department of Physical Therapy, Arcadia University, Glenside, Pennsylvania

5. Oregon Health & Science University, Shriners Hospitals for Children, Portland, Oregon

6. Advanced Imaging Research Center, Oregon Health & Science University

Abstract

Abstract Duchenne muscular dystrophy (DMD) is a muscle degenerative disorder that manifests in early childhood and results in progressive muscle weakness. Physical therapists have long been an important component of the multidisciplinary team caring for people with DMD, providing expertise in areas of disease assessment, contracture management, assistive device prescription, and exercise prescription. Over the last decade, magnetic resonance imaging of muscles in people with DMD has led to an improved understanding of the muscle pathology underlying the clinical manifestations of DMD. Findings from magnetic resonance imaging (MRI) studies in DMD, paired with the clinical expertise of physical therapists, can help guide research that leads to improved physical therapist care for this unique patient population. The 2 main goals of this perspective article are to (1) summarize muscle pathology and disease progression findings from qualitative and quantitative muscle MRI studies in DMD and (2) link MRI findings of muscle pathology to the clinical manifestations observed by physical therapists with discussion of any potential implications of MRI findings on physical therapy management.

Funder

National Institute of Arthritis and Musculoskeletal and Skin Diseases

National Institute of Neurological Disorders and Stroke

National Institutes of Health

National Heart, Lung, and Blood Institute

Publisher

Oxford University Press (OUP)

Subject

Physical Therapy, Sports Therapy and Rehabilitation

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