Ayurvedic treatment induced severe alcoholic hepatitis and non-cirrhotic portal hypertension in a 14-year-old girl-Reference-Cited by-同舟云学术

Ayurvedic treatment induced severe alcoholic hepatitis and non-cirrhotic portal hypertension in a 14-year-old girl

Published:2022-10-01 Issue:10 Volume:2022 Page:
ISSN:2053-8855
Container-title:Oxford Medical Case Reports
language:en
Short-container-title:

Author:

Philips Cyriac Abby¹^ORCID,Ahamed Rizwan²,Abduljaleel Jinsha K²,Rajesh Sasidharan³,Theruvath Arif Hussain⁴,Raveendran Resmi⁵,Augustine Philip²

Affiliation:

1. Rajagiri Hospital Clinical and Translational Hepatology & Monarch Liver Laboratory, The Liver Institute, Center of Excellence in GI Sciences, , Aluva, Kerala, India

2. Rajagiri Hospital Gastroenterology & Advanced GI Endoscopy, Center of Excellence in GI Sciences, , Aluva, Kerala, India

3. Rajagiri Hospital Interventional Hepatobiliary Radiology, The Liver Institute, Center of Excellence in GI Sciences, , Aluva, Kerala, India

4. Rajagiri Hospital Division of Complementary and Alternative Medicine (Homoeopathy), Department of Clinical Research, The Liver Institute, Center for Excellence in Gastrointestinal Sciences, , Aluva, Kerala, India

5. Rajagiri Hospital Division of Complementary and Alternative Medicine (Ayurveda), Department of Clinical Research, The Liver Institute, Center for Excellence in Gastrointestinal Sciences, , Aluva, Kerala, India

Abstract

ABSTRACTWe report a novel and as yet undescribed clinical scenario in a young girl with liver failure, in whom, the liver histopathology was suggestive of alcoholic hepatitis in the background of hepatoportal sclerosis and incomplete septal cirrhosis. An extensive clinical and investigational evaluation revealed chronic consumption of multiple Ayurvedic herbal medications for seizure disease. Six months after stopping herbal medicines, the repeat liver biopsy demonstrated resolution of alcohol-related changes but persistence of classical features of non-cirrhotic portal hypertension. Analysis of the retrieved agents, including state of the art chemical and toxicology analysis, using gas chromatography and mass spectroscopy methods demonstrated multiple organic and inorganic toxins associated with acute alcohol and arsenic poisoning related hepatoportal sclerosis/incomplete septal cirrhosis in the young girl.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology,Parasitology

Link

https://academic.oup.com/omcr/article-pdf/2022/10/omac113/46607143/omac113.pdf

Reference21 articles.

1. Alcoholic liver disease: pathogenesis and current management;Osna;Alcohol Res,2017

2. Severe alcoholic hepatitis in a teetotaler;Philips;Am J Gastroenterol,2018

3. Homeopathy-medicine induced severe alcoholic hepatitis;Philips;BMJ Case Rep,2019

4. Idiopathic non-cirrhotic portal hypertension: a review;Schouten;Orphanet J Rare Dis,2015

5. Noncirrhotic portal hypertension;Da;Curr Opin Gastroenterol,2018