A comprehensive evaluation of the genetic architecture of sudden cardiac arrest

Author:

Ashar Foram N1,Mitchell Rebecca N1,Albert Christine M2,Newton-Cheh Christopher3,Brody Jennifer A4,Müller-Nurasyid Martina5678,Moes Anna1,Meitinger Thomas8910,Mak Angel11,Huikuri Heikki12,Junttila M Juhani12,Goyette Philippe13,Pulit Sara L14,Pazoki Raha15,Tanck Michael W16,Blom Marieke T17,Zhao XiaoQing18,Havulinna Aki S19,Jabbari Reza20,Glinge Charlotte20,Tragante Vinicius21,Escher Stefan A22,Chakravarti Aravinda1,Ehret Georg1,Coresh Josef23,Li Man23,Prineas Ronald J24,Franco Oscar H2526,Kwok Pui-Yan11,Lumley Thomas27,Dumas Florence28,McKnight Barbara429,Rotter Jerome I30,Lemaitre Rozenn N4,Heckbert Susan R31,O’Donnell Christopher J3233,Hwang Shih-Jen33,Tardif Jean-Claude13,VanDenburgh Martin2,Uitterlinden André G34,Hofman Albert26,Stricker Bruno H C26,de Bakker Paul I W3536,Franks Paul W22,Jansson Jan-Hakan37,Asselbergs Folkert W213839,Halushka Marc K40,Maleszewski Joseph J41,Tfelt-Hansen Jacob2042,Engstrøm Thomas2043,Salomaa Veikko19,Virmani Renu18,Kolodgie Frank18,Wilde Arthur A M44,Tan Hanno L44,Bezzina Connie R44,Eijgelsheim Mark45,Rioux John D13,Jouven Xavier28,Kääb Stefan78,Psaty Bruce M46,Siscovick David S47,Arking Dan E1,Sotoodehnia Nona48

Affiliation:

1. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins, 733 N Broadway, Baltimore, MD, USA

2. Divisions of Preventive Medicine and Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, 900 Commonwealth Ave East, 3rd Floor, Boston, MA, USA

3. Center for Human Genetic Research & Cardiovascular Research Center, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, USA

4. Cardiovascular Health Research Unit, Department of Medicine, University of Washington, 1730 Minor Ave, Seattle, WA, USA

5. Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Ingolstädter Landstraße 1, Neuherberg, Germany

6. Chair of Genetic Epidemiology, Institute for Medical Informatics, Biometry and Epidemiology, Faculty of Medicine, Ludwig-Maximilians University, Marchioninistr. 15, Munich, Germany

7. Department of Internal Medicine I (Cardiology), Hospital of the Ludwig-Maximilians-University, Marchioninistr. 15, Munich, Germany

8. DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Biedersteiner Strasse 29, Munich, Germany

9. Institute of Human Genetics, Helmholtz Zentrum München - German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, Neuherberg, Germany

10. Institute of Human Genetics, Klinikum rechts der Isar, Technische Universität München, Ismaninger Strasse 22, Munich, Germany

11. Cardiovascular Research Institute and Institute for Human Genetics, University of California, San Francisco, 1550 4th Street, San Francisco, CA, USA

12. Research Unit of Internal Medicine, University Hospital and University of Oulu, Kajaaninkatu 50, Oulu, Finland

13. Montreal Heart Institute, Université de Montréal, 5000 rue Bélanger, Montréal, Quebec, Canada

14. Department of Genetics, Center for Molecular Medicine, University Medical Centre Utrecht, Heidelberglaan 100, Utrecht, The Netherlands

15. Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary's Hospital, Praed St, Paddington, London, UK

16. Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, Meibergdreef 9, AZ Amsterdam, The Netherlands

17. Department of Clinical and Experimental Cardiology, Heart Center, Academic Medical Center, Meibergdreef 9, AZ Amsterdam, The Netherlands

18. CVPath Institute, 19 Firstfield Road, Gaithersburg, MD, USA

19. National Institute for Health and Welfare, Mannerheimintie 166, Helsinki, Finland

20. Department of Cardiology, Rigshospitalet, Inge Lehmanns Vej 7, Copenhagen, Denmark

21. Department of Cardiology, Division Heart & Lungs, University Medical Center Utrecht, University of Utrecht, Heidelberglaan 100, Utrecht, The Netherlands

22. Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, Barngatan 4, Skånes universitetssjukhus, Malmo, Sweden

23. Department of Epidemiology, Johns Hopkins University, 615 N Wolfe Street, Baltimore, MD, USA

24. Public Health Sciences, Wake Forest University, Medical Center Boulevard, Winston-Salem, NC, USA

25. Institute of Social and Preventative Medicine, University of Bern, Mittelstrasse 43, Bern, Switzerland

26. Department of Epidemiology, Erasmus MC, Dr. Molewaterplein 50, GE Rotterdam, The Netherlands

27. Department of Statistics, University of Auckland, Private Bag 92014, Auckland, New Zealand

28. Paris Sudden Death Expertise Center, University Paris Descartes, Sorbonne Paris Cité, INSERM U970, 56 rue Leblanc, Paris, France

29. Department of Biostatistics, University of Washington, F-600, Health Sciences Building 1705 NE Pacific Street, Seattle, WA, USA

30. The Institute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, 1124 W. Carson Street, Torrance, CA, USA

31. Cardiovascular Health Research Unit, Department of Epidemiology, University of Washington, 1959 NE Pacific St, Seattle, WA, USA

32. NHLBI Framingham Heart Study, 73 Mount Wayte Avenue, Suite #2, Framingham, MA, USA

33. Cardiology Section, Department of Medicine, Boston VA Healthcare System, 1400 VFW Parkway, Boston, MA, USA

34. Erasmus MC University Medical Center, Department of Internal Medicine, Dr. Molewaterplein 40, CD Rotterdam, The Netherlands

35. Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, The Netherlands

36. Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, The Netherlands

37. Department of Public Health and Clinical Medicine, Research Unit Skelleftea, Umea University, University Hospital, Building 1A, 4st, Umea, Sweden

38. Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, 69-75 Chenies Mews, London, UK

39. Institute of Health Informatics, University College London, 222 Euston Road London, UK

40. Department of Pathology, Division of Cardiovascular Pathology, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross Rm 632B, Baltimore, MD, USA

41. Department of Laboratory Medicine & Pathology, Mayo Clinic, 3050 Superior Drive, Rochester, MN, USA

42. Department of Forensic Medicine, Faculty of Medical Sciences, University of Copenhagen, Inge Lehmanns Vej 7, Copenhagen, Denmark

43. Department of Cardiology, University of Lund, Getingevägen 4, Lund, Sweden

44. Amsterdam UMC, University of Amsterdam, Heart Center; Department of Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences, Meibergdreef 9, AZ, Amsterdam, The Netherlands

45. Department of Nephrology, University Medical Center Groningen, Hanzeplein 1, GZ, Groningen, The Netherlands

46. Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, 1730 Minor Ave, suite #1360, Seattle, WA, USA

47. The New York Academy of Medicine, 1216 5th Ave, New York, New York, USA

48. Cardiovascular Health Research Unit, Division of Cardiology, Departments of Medicine and Epidemiology, University of Washington, 1730 Minor Ave, Seattle, WA, USA

Funder

Netherlands Heart Foundation

CVON project PREDICT

Leducq Foundation

Center for Translational Molecular Medicine

Netherlands Organization for Scientific Research

European Union’s Horizon 2020 research and innovation programme

Medicines Evaluation Board Netherlands

National Heart, Lung, and Blood Institute

National Human Genome Research Institute

National Institutes of Health

NIH Roadmap for Medical Research

John Locke and Medic One Foundations

National Institute of Neurological Disorders and Stroke

National Institute on Aging

National Center for Advancing Translational Sciences

National Institute of Diabetes and Digestive and Kidney Disease Diabetes Research Center

United States Department of Agriculture Research Service

National Heart, Lung, and Blood Institute Framingham Heart Study

Affymetrix, Inc

Sigrid Juselius Foundation

National Cancer Institute

Netherlands Organisation of Scientific Research NWO Investments

Research Institute for Diseases in the Elderly

Netherlands Genomics Initiative

Netherlands Organisation for Scientific Research

Publisher

Oxford University Press (OUP)

Subject

Cardiology and Cardiovascular Medicine

Reference32 articles.

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