Sildenafil for improving outcomes in patients with corrected valvular heart disease and persistent pulmonary hypertension: a multicenter, double-blind, randomized clinical trial
Author:
Bermejo Javier1, Yotti Raquel1, García-Orta Rocío2, Sánchez-Fernández Pedro L3, Castaño Mario4, Segovia-Cubero Javier5, Escribano-Subías Pilar6, San Román José Alberto7, Borrás Xavier8, Alonso-Gómez Angel9, Botas Javier10, Crespo-Leiro María G11, Velasco Sonia12, Bayés-Genís Antoni13, López Amador14, Muñoz-Aguilera Roberto15, de Teresa Eduardo16, González-Juanatey José R17, Evangelista Arturo18, Mombiela Teresa1, González-Mansilla Ana1, Elízaga Jaime1, Martín-Moreiras Javier3, González-Santos José M3, Moreno-Escobar Eduardo19, Fernández-Avilés Francisco1, Bermejo Javier, Yotti Raquel, Mombiela Teresa, Gónzález-Mansilla Ana, Elízaga Jaime, García-Robles José A, Pérez-David Esther, Pérez del Villar Candelas, Sanz Ricardo, Gutierrez-Ibanes Enrique, Vázquez María E, Mur Ana, Benito Yolanda, Martínez-Legazpi Pablo, Barrio Alicia, Vázquez Alexandra, García-Orta Rocío, Uribe Inés, González Mercedes, Luis Sánchez Pedro, González-Santos José M, Martín-Moreiras Javier, Arribas Antonio, Clemente Lorenzo M Milagros, Diego Nieto Alejandro, Castaño Mario, Pérez de Prado Armando, Alonso David, Segovia-Cubero Javier, Gómez-Bueno Manuel, Sayago Silva Inés, Ángel Cavero Miguel, Escribano-Subias Pilar, Domínguez Laura, Tello de Meneses Rocío, Ruiz Cano M José, Jiménez López-Guarch Carmen, San Román J Alberto, Mota Pedro, Borrás Xavier, Amorós Galitó Carmen, Alonso-Gómez Angel, Belló Mora M Concepción, Mesa Rubio Dolores, Botas Javier, Campuzano Raquel, Crespo-Leiro María G, Marzoa Raquel, Cuenca José, Velasco Sonia, Muñoz Roberto, Suberviola Verónica, Beltrán Herrera Cristina, Mora Laura, Mar Sarrión M, Vaqueriza David, Bayes-Genís Antoni, Ferrer Elena, González-Juanatey José R, Cid Belén, Monzonís Amparo Martínez, López Amador, Arizón de Prado José M, Santisteban Marta, Mesa Rubio Dolores, Evangelista Arturo, García-Dorado David, de Teresa Eduardo, Jiménez-Navarro Manuel, Carrasco Chinchilla Fernando, Moreno-Escobar Eduardo, Alonso Joaquín,
Affiliation:
1. Department of Cardiology, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Facultad de Medicina, Universidad Complutense de Madrid, and CIBERCV. Dr Esquerdo 46. 28007 Madrid, Spain 2. Hospital Virgen de las Nieves, Granada 3. Hospital Clínico Universitario de Salamanca, and CIBERCV Salamanca 4. Hospital Universitario de León, León 5. Hospital Puerta de Hierro Majadahonda and CIBERCV, Majadahonda 6. Hospital 12 de Octubre and CIBERCV, Madrid, Spain 7. Hospital Clínico de Valladolid and CIBERCV, Valladolid 8. Hospital Santa Creu i San Pau and CIBERCV, Barcelona 9. Hospital Universitario de Araba-Txagorritxu, Vitoria 10. Hospital Universitario Fundación Alcorcón, Alcorcón 11. Complejo Hospitalario Universitario de A Coruña and CIBERCV, A Coruña 12. Hospital de Galdakao-Usansolo, Usansolo 13. Hospital Universitari Germans Trias i Pujol and CIBERCV, Badalona 14. Hospital Universitario Reina Sofía, Córdoba 15. Hospital Infanta Leonor, Madrid 16. Hospital Virgen de la Victoria and CIBERCV, Málaga 17. Hospital Clínico de Santiago de Compostela and CIBERCV, Santiago de Compostela 18. Hospital Universitario de la Vall d’Hebron and CIBERCV, Barcelona 19. Hospital Universitario San Cecilio, Granada, Spain
Funder
European Regional Development Fund
Publisher
Oxford University Press (OUP)
Subject
Cardiology and Cardiovascular Medicine
Reference32 articles.
1. 2015 ESC/ERS guidelines for the diagnosis and treatment of pulmonary hypertension: the Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT);Galie;Eur Heart J,2016 2. Pulmonary hypertension with left heart disease: prevalence, temporal shifts in etiologies and outcome;Weitsman;Am J Med,2017 3. 2017 ESC/EACTS Guidelines for the management of valvular heart disease;Baumgartner;Eur Heart J,2017 4. Pulmonary hypertension in valvular disease: a comprehensive review on pathophysiology to therapy from the HAVEC Group;Magne;JACC Cardiovasc Imaging,2015 5. Impact of valve prosthesis-patient mismatch on pulmonary arterial pressure after mitral valve replacement;Li;J Am Coll Cardiol,2005
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