1. Department of Clinical and Molecular Medicine, Sapienza University of Rome , Via di Grottarossa 1035-1039, Rome 00189 , Italy
2. IRCCS San Raffaele , Via della Pisana 235, Rome 00163 , Italy
3. Department of Cardiovascular Medicine, Fondazione Policlinico Universitario A. Gemelli—IRCCS , Largo A. Gemelli 8, Rome 00168 , Italy
4. Cardiovascular and Pulmonary Sciences, Catholic University, School of Medicine , Largo F. Vito, Rome 1–00168 , Italy