Cardiac biomarkers for diagnosing Takotsubo syndrome

Author:

Schweiger Victor1,Di Vece Davide23,Cammann Victoria L1,Koleva Iva1,Würdinger Michael1,Gilhofer Thomas1,Rajman Katja1,Szawan Konrad A1,Niederseer David1ORCID,Citro Rodolfo45ORCID,Vecchione Carmine56ORCID,Bossone Eduardo7ORCID,Gili Sebastiano8,Neuhaus Michael9,Franke Jennifer10,Meder Benjamin10ORCID,Jaguszewski Miłosz11,Noutsias Michel12,Knorr Maike13,Jansen Thomas13,D’Ascenzo Fabrizio14,Bruno Francesco1415ORCID,De Filippo Ovidio15ORCID,Stefanini Giulio1617,Campo Gianluca18ORCID,Wanha Wojciech19,Raposeiras Roubin Sergio20,Dichtl Wolfgang21,von Lewinski Dirk22ORCID,Burgdorf Christof23,Kherad Behrouz24,Tschöpe Carsten24ORCID,Sarcon Annahita25,Shinbane Jerold26,Rajan Lawrence27,Michels Guido28,Pfister Roman29ORCID,Cuneo Alessandro30,Jacobshagen Claudius3132,Karakas Mahir3334,Koenig Wolfgang3536ORCID,Pott Alexander37,Meyer Philippe38ORCID,Roffi Marco38,Banning Adrian39ORCID,Wolfrum Mathias40,Cuculi Florim40,Kobza Richard40ORCID,Fischer Thomas A41,Vasankari Tuija42,Airaksinen K E Juhani42,Napp L Christian43,Dworakowski Rafal44,MacCarthy Philip44,Kaiser Christoph45,Osswald Stefan45,Galiuto Leonarda46ORCID,Chan Christina47,Bridgman Paul47,Beug Daniel4849,Delmas Clément50,Lairez Olivier50ORCID,Gilyarova Ekaterina51,Shilova Alexandra51,Gilyarov Mikhail51ORCID,El-Battrawy Ibrahim5253,Akin Ibrahim5253ORCID,Poledniková Karolina54,Toušek Petr54,Winchester David E55,Massoomi Michael55,Galuszka Jan56,Ukena Christian57ORCID,Poglajen Gregor58,Carrilho-Ferreira Pedro59,Hauck Christian60ORCID,Paolini Carla61ORCID,Bilato Claudio61ORCID,Kobayashi Yoshio62,Kato Ken62,Ishibashi Iwao63,Himi Toshiharu64,Din Jehangir65,Al-Shammari Ali65,Prasad Abhiram66,Rihal Charanjit S66,Liu Kan67,Schulze P Christian68,Bianco Matteo69,Jörg Lucas70,Rickli Hans70,Pestana Gonçalo71,Nguyen Thanh H72,Böhm Michael57ORCID,Maier Lars S60,Pinto Fausto J59,Widimský Petr54ORCID,Felix Stephan B4849,Braun-Dullaeus Ruediger C73,Rottbauer Wolfgang37ORCID,Hasenfuß Gerd31,Pieske Burkert M2474,Schunkert Heribert3536ORCID,Budnik Monika75,Opolski Grzegorz75,Thiele Holger76ORCID,Bauersachs Johann43ORCID,Horowitz John D72,Di Mario Carlo77ORCID,Kong William78,Dalakoti Mayank78,Imori Yoichi79,Münzel Thomas13,Bax Jeroen J80ORCID,Lüscher Thomas F1581,Crea Filippo46,Ruschitzka Frank1,Ghadri Jelena R81,Templin Christian182ORCID

Affiliation:

1. Department of Cardiology, University Heart Center, University Hospital Zurich, University of Zurich , Rämistrasse 100, 8091 Zurich , Switzerland

2. First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa , Genoa , Italy

3. Internal Medicine B, University Medicine Greifswald , Greifswald , Germany

4. Heart Department, University Hospital ‘San Giovanni di Dio e Ruggi d’Aragona’ , Salerno , Italy

5. Department of Vascular Physiopathology, IRCCS Neuromed , Pozzilli , Italy

6. Department of Medicine, Surgery and Dentistry, University of Salerno , Baronissi, Salerno , Italy

7. Division of Cardiology, ‘Antonio Cardarelli’ Hospital , Naples , Italy

8. Centro Cardiologico Monzino, IRCCS , Milan , Italy

9. Department of Cardiology, Kantonsspital Frauenfeld , Frauenfeld , Switzerland

10. Department of Cardiology, Heidelberg University Hospital , Heidelberg , Germany

11. First Department of Cardiology, Medical University of Gdansk , Gdansk , Poland

12. Mid-German Heart Center, Department of Internal Medicine III, Division of Cardiology, Angiology and Intensive Medical Care, University Hospital Halle, Martin-Luther-University Halle-Wittenberg , Halle (Saale) , Germany

13. Center for Cardiology, Cardiology 1, University Medical Center Mainz , Mainz , Germany

14. Division of Cardiology, Department of Medical Sciences, AOU Città della Salute e della Scienza, University of Turin , Turin , Italy

15. Royal Brompton and Harefield Hospitals Trust and Imperial College , London , UK

16. Department of Biomedical Sciences, Humanitas University , Pieve Emanuele, Milan , Italy

17. Humanitas Research Hospital IRCCS , Rozzano, Milan , Italy

18. Azienda Ospedaliero-Universitaria di Ferrara , University of Ferrara , Italy

19. Medical University of Silesia , Katowice , Poland

20. Hospital Álvaro Cunqueiro , Vigo , Spain

21. University Hospital for Internal Medicine III (Cardiology and Angiology), Medical University Innsbruck , Innsbruck , Austria

22. Division of Cardiology, Medical University of Graz , Graz , Austria

23. Heart and Vascular Centre Bad Bevensen , Bad Bevensen , Germany

24. Department of Cardiology, Charité, Campus Rudolf Virchow , Berlin , Germany

25. Section of Cardiac Electrophysiology, Department of Medicine, University of California-San Francisco , San Francisco, CA , USA

26. University of Southern California, Keck School of Medicine , Los Angeles, CA , USA

27. TJ Health Partners Heart and Vascular , Glasgow, KY , USA

28. Klinik für Akut- und Notfallmedizin, St.-Antonius-Hospital gGmbH, Akademisches Lehrkrankenhaus der RWTH Aachen , Eschweiler , Germany

29. Department of Internal Medicine III, Heart Center University of Cologne , Cologne , Germany

30. Krankenhaus ‘Maria Hilf’ Medizinische Klinik , Stadtlohn , Germany

31. Clinic for Cardiology and Pneumology, Georg August University Goettingen , Goettingen , Germany

32. Vincentius-Diakonissen Hospital , Karlsruhe , Germany

33. Department of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf , Hamburg , Germany

34. DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Luebeck , Hamburg , Germany

35. Deutsches Herzzentrum München, Technische Universität München , Munich , Germany

36. DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance , Munich , Germany

37. Department of Internal Medicine II—Cardiology, University of Ulm, Medical Center , Ulm , Germany

38. Service de cardiologie, Hôpitaux Universitaires de Genève , Geneva , Switzerland

39. Department of Cardiology, John Radcliffe Hospital, Oxford University Hospitals , Oxford , UK

40. Department of Cardiology, Kantonsspital Lucerne , Lucerne , Switzerland

41. Department of Cardiology, Kantonsspital Winterthur , Winterthur , Switzerland

42. Heart Center, Turku University Hospital and University of Turku , Turku , Finland

43. Department of Cardiology and Angiology, Hannover Medical School , Hannover , Germany

44. Department of Cardiology, King’s College Hospital , London , UK

45. Department of Cardiology, University Hospital Basel , Basel , Switzerland

46. Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore , Rome , Italy

47. Department of Cardiology, Christchurch Hospital , Christchurch , New Zealand

48. Department of Cardiology and Internal Medicine B, University Medicine Greifswald , Germany

49. DZHK (German Centre for Cardiovascular Research), partner site Greifswald , Greifswald , Germany

50. Department of Cardiology and Cardiac Imaging Center, University Hospital of Rangueil , Toulouse , France

51. Intensive Coronary Care Unit, Pirogov Clinical City Hospital No. 1 , Moscow , Russia

52. First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM) University of Heidelberg , Mannheim , Germany

53. DZHK (German Center for Cardiovascular Research), partner site, Heidelberg-Mannheim , Mannheim , Germany

54. Cardiocenter, Third Faculty of Medicine, Charles University in Prague and University Hospital Královské Vinohrady , Prague , Czech Republic

55. Division of Cardiovascular Medicine, Department of Medicine, College of Medicine, University of Florida , Gainesville, FL , USA

56. Department of Internal Medicine I—Cardiology, University Hospital Olomouc , Olomouc , Czech Republic

57. Klinik für Innere Medizin III, Universitätsklinikum des Saarlandes , Homburg/Saar , Germany

58. Advanced Heart Failure and Transplantation Center, University Medical Center Ljubljana , Ljubljana , Slovenia

59. Santa Maria University Hospital, CHULN, Center of Cardiology of the University of Lisbon, Lisbon School of Medicine, Lisbon Academic Medical Center , Lisboa , Portugal

60. Klinik und Poliklinik für Innere Medizin II, Universitätsklinikum Regensburg , Regensburg , Germany

61. Local Health Unit n.8, Cardiology Unit , Arzignano, Vicenza , Italy

62. Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine , Chiba , Japan

63. Department of Cardiology, Chiba Emergency Medical Center , Chiba , Japan

64. Division of Cardiology, Kimitsu Central Hospital , Kisarazu , Japan

65. Dorset Heart Centre, Royal Bournemouth Hospital , Bournemouth , UK

66. Department of Cardiovascular Diseases, Mayo Clinic , Rochester, MN , USA

67. Division of Cardiology, Heart and Vascular Center, University of Iowa , Iowa City, IA , USA

68. Department of Internal Medicine I, University Hospital Jena, Friedrich-Schiller-University Jena , Jena , Germany

69. Division of Cardiology, A.O.U San Luigi Gonzaga , Orbassano, Turin , Italy

70. Department of Cardiology, Kantonsspital St. Gallen , St. Gallen , Switzerland

71. Department of Cardiology, Centro Hospitalar Universitário de São João, E.P.E. , Porto , Portugal

72. Department of Cardiology, Basil Hetzel Institute, Queen Elizabeth Hospital, University of Adelaide , Adelaide , Australia

73. Department of Internal Medicine, Cardiology and Angiology, Magdeburg University , Magdeburg , Germany

74. Berlin Institute of Health (BIH) , Berlin , Germany

75. Department of Cardiology, Medical University of Warsaw , Warsaw , Poland

76. Department of Internal Medicine/Cardiology, Heart Center Leipzig—University Hospital , Leipzig , Germany

77. Structural Interventional Cardiology, Careggi University Hospital , Florence , Italy

78. Department of Cardiology, National University Heart Centre , Singapore , Singapore

79. Department of Cardiovascular Medicine, Nippon Medical School , Tokyo , Japan

80. Department of Cardiology, Leiden University Medical Centre , Leiden , The Netherlands

81. Center for Molecular Cardiology, Schlieren Campus, University of Zurich , Zurich , Switzerland

82. Swiss CardioVascularClinic, Private Hospital Bethanien , Zurich , Switzerland

Publisher

Oxford University Press (OUP)

Reference10 articles.

1. Clinical features and outcomes of Takotsubo (stress) cardiomyopathy;Templin;N Engl J Med,2015

2. International expert consensus document on Takotsubo syndrome (part II): diagnostic workup, outcome, and management;Ghadri;Eur Heart J,2018

3. Hemodynamic assessment in Takotsubo syndrome;Stiermaier;J Am Coll Cardiol,2023

4. A systematic review of biomarkers in Takotsubo syndrome: a focus on better understanding the pathophysiology;Khan;Int J Cardiol Heart Vasc,2021

5. Value of cardiac biomarkers in the early diagnosis of Takotsubo syndrome;Dagrenat;J Clin Med,2020

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