Polygenic risk scores for cardiovascular risk prediction: moving towards implementation into clinical practice?
Author:
Affiliation:
1. Department of Clinical Biochemistry, Copenhagen University Hospital—Rigshospitalet , Copenhagen , Denmark
2. Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen , Denmark
Publisher
Oxford University Press (OUP)
Link
https://academic.oup.com/eurheartj/article-pdf/45/20/1853/57927962/ehae125.pdf
Reference15 articles.
1. Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations;Khera;Nat Genet,2018
2. Predictive accuracy of a polygenic risk score compared with a clinical risk score for incident coronary heart disease;Mosley;JAMA,2020
3. Limitations of contemporary guidelines for managing patients at high genetic risk of coronary artery disease;Aragam;J Am Coll Cardiol,2020
4. The clinical application of polygenic risk scores: a points to consider statement of the American College of Medical Genetics and Genomics (ACMG);Abu-El-Haija;Genet Med,2023
5. Design and user experience testing of a polygenic score report: a qualitative study of prospective users;Brockman;BMC Med Genomics,2021
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