DisProt in 2022: improved quality and accessibility of protein intrinsic disorder annotation-Reference-Cited by-同舟云学术

DisProt in 2022: improved quality and accessibility of protein intrinsic disorder annotation

Published:2021-11-25 Issue:D1 Volume:50 Page:D480-D487
ISSN:0305-1048
Container-title:Nucleic Acids Research
language:en
Short-container-title:

Author:

Quaglia Federica¹²^ORCID,Mészáros Bálint³^ORCID,Salladini Edoardo²^ORCID,Hatos András²^ORCID,Pancsa Rita⁴^ORCID,Chemes Lucía B⁵^ORCID,Pajkos Mátyás⁶^ORCID,Lazar Tamas⁷⁸^ORCID,Peña-Díaz Samuel⁹¹⁰^ORCID,Santos Jaime⁹¹⁰^ORCID,Ács Veronika⁴^ORCID,Farahi Nazanin⁷⁸^ORCID,Fichó Erzsébet⁴¹¹^ORCID,Aspromonte Maria Cristina¹²¹³^ORCID,Bassot Claudio¹⁴^ORCID,Chasapi Anastasia¹⁵^ORCID,Davey Norman E¹⁶^ORCID,Davidović Radoslav¹⁷^ORCID,Dobson Laszlo³⁴^ORCID,Elofsson Arne¹⁴^ORCID,Erdős Gábor⁶^ORCID,Gaudet Pascale¹⁸^ORCID,Giglio Michelle¹⁹^ORCID,Glavina Juliana⁵^ORCID,Iserte Javier²⁰^ORCID,Iglesias Valentín⁹¹⁰^ORCID,Kálmán Zsófia²¹^ORCID,Lambrughi Matteo²²^ORCID,Leonardi Emanuela¹²¹³^ORCID,Longhi Sonia²³^ORCID,Macedo-Ribeiro Sandra²⁴²⁵^ORCID,Maiani Emiliano²²^ORCID,Marchetti Julia²⁶^ORCID,Marino-Buslje Cristina²⁰^ORCID,Mészáros Attila⁷⁸^ORCID,Monzon Alexander Miguel²^ORCID,Minervini Giovanni²^ORCID,Nadendla Suvarna¹⁹^ORCID,Nilsson Juliet F²³^ORCID,Novotný Marian²⁷^ORCID,Ouzounis Christos A¹⁵²⁸^ORCID,Palopoli Nicolás²⁶^ORCID,Papaleo Elena²²²⁹^ORCID,Pereira Pedro José Barbosa²⁴²⁵^ORCID,Pozzati Gabriele¹⁴^ORCID,Promponas Vasilis J³⁰^ORCID,Pujols Jordi⁹¹⁰^ORCID,Rocha Alma Carolina Sanchez³¹^ORCID,Salas Martin²⁶^ORCID,Sawicki Luciana Rodriguez²⁶^ORCID,Schad Eva⁴^ORCID,Shenoy Aditi¹⁴^ORCID,Szaniszló Tamás⁶^ORCID,Tsirigos Konstantinos D³²^ORCID,Veljkovic Nevena¹⁷^ORCID,Parisi Gustavo²⁶^ORCID,Ventura Salvador⁹¹⁰³³^ORCID,Dosztányi Zsuzsanna⁶^ORCID,Tompa Peter⁴⁷⁸^ORCID,Tosatto Silvio C E²^ORCID,Piovesan Damiano²^ORCID

Affiliation:

1. Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies, National Research Council (CNR-IBIOM), Bari, Italy

2. Department of Biomedical Sciences, University of Padova, Padova, Italy

3. Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg 69117, Germany

4. Institute of Enzymology, Research Centre for Natural Sciences, Budapest 1117, Hungary

5. Instituto de Investigaciones Biotecnológicas (IIBiO-CONICET), Universidad Nacional de San Martín, Av. 25 de Mayo y Francia, CP1650 Buenos Aires, Argentina

6. Department of Biochemistry, Eötvös Loránd University, Pázmány Péter stny 1/c, Budapest H-1117, Hungary

7. VIB-VUB Center for Structural Biology, Vlaams Instituut voor Biotechnology, Brussels, Belgium

8. Structural Biology Brussels (SBB), Bioengineering Sciences Department, Vrije Universiteit Brussel (VUB), Brussels, Belgium

9. Institut de Biotecnologia i Biomedicina, Universitat Autònoma de Barcelona, Barcelona, Spain

10. Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Barcelona, Spain

11. Cytocast Kft., Vecsés, Hungary

12. Department of Woman and Child Health, University of Padova, Padova, Italy

13. Pediatric Research Institute, Città della Speranza, Padova, Italy

14. Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, 171 21 Solna, Sweden

15. Biological Computation & Process Laboratory, Chemical Process & Energy Resources Institute, Centre for Research & Technology Hellas, Thermi, Thessalonica 57001, Greece

16. Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Rd, Chelsea, London, UK

17. Laboratory for Bioinformatics and Computational Chemistry, Vinča Institute of Nuclear Sciences, National Institute of the Republic of Serbia, University of Belgrade, 11000Belgrade, Serbia

18. Swiss-Prot group, SIB Swiss Institute of Bioinformatics, Geneva, Switzerland

19. Institute for Genome Sciences, University of Maryland School of Medicine 670 W. Baltimore St., Baltimore, MD 21201, USA

20. Bioinformatics Unit, Fundación Instituto Leloir, Buenos Aires, C1405BWE, Argentina

21. Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Práter u. 50/A, 1083 Budapest, Hungary

22. Cancer Structural Biology, Danish Cancer Society Research Center, Strandboulevarden 49, 2100 Copenhagen, Denmark

23. Lab. Architecture et Fonction des Macromolécules Biologiques (AFMB), UMR 7257, Aix Marseille University and Centre National de la Recherche Scientifique (CNRS), 163 Avenue de Luminy, Case 932, 13288, Marseille, France

24. Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, 4200-135 Porto, Portugal

25. Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, 4200-135 Porto, Portugal

26. Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes - CONICET, Bernal, Buenos Aires B1876BXD, Argentina

27. Dep. of Cell Biology, Faculty of Science, Vinicna 7, 128 43, Prague, Czech Republic

28. Biological Computation & Computational Biology Group, Artificial Intelligence & Information Analysis Lab, Department of Computer Science, Aristotle University of Thessalonica, Thessalonica 54124, Greece

29. Cancer Systems Biology, Section for Bioinformatics, Department of Health and Technology, Technical University of Denmark, Lyngby, Denmark

30. Bioinformatics Research Laboratory, Department of Biological Sciences, University of Cyprus, Nicosia, Cyprus

31. Department of Cell Biology, Faculty of Science, Charles University, BIOCEV, Prague , Czech Republic

32. European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, UK

33. ICREA, Barcelona, Spain

Abstract

Abstract The Database of Intrinsically Disordered Proteins (DisProt, URL: https://disprot.org) is the major repository of manually curated annotations of intrinsically disordered proteins and regions from the literature. We report here recent updates of DisProt version 9, including a restyled web interface, refactored Intrinsically Disordered Proteins Ontology (IDPO), improvements in the curation process and significant content growth of around 30%. Higher quality and consistency of annotations is provided by a newly implemented reviewing process and training of curators. The increased curation capacity is fostered by the integration of DisProt with APICURON, a dedicated resource for the proper attribution and recognition of biocuration efforts. Better interoperability is provided through the adoption of the Minimum Information About Disorder (MIADE) standard, an active collaboration with the Gene Ontology (GO) and Evidence and Conclusion Ontology (ECO) consortia and the support of the ELIXIR infrastructure.

Funder

Italian Ministry of University and Research

Horizon 2020

Marie Skłodowska-Curie

Tempus Public Foundation

NRDI Office

National Agency for the Promotion of Science and Technology

Spanish Ministry of Science and Innovation

Marie Sklodowska-Curie

Swedish Research Council for Natural Science

Swedish E-science Research Center

National Human Genome Research Institute