Macrophage polarization in diabetic wound healing

Author:

Wu Xingqian1ORCID,He Wenjie1,Mu Xingrui1,Liu Ye1,Deng Junyu1,Liu Yiqiu1ORCID,Nie Xuqiang1234ORCID

Affiliation:

1. Zunyi Medical University College of Pharmacy, , Zunyi 563000, China

2. Zunyi Medical University Joint International Research Laboratory of Ethnomedicine of Chinese Ministry of Education, , Zunyi 563000, China

3. Zunyi Medical University Key Lab of the Basic Pharmacology of the Ministry of Education, , Zunyi 563000, China

4. Queensland University of Technology Cancer and Ageing Research Program, School of Biomedical Sciences, , 37 Kent Street, Woolloongabba, Brisbane 4102, Australia

Abstract

Abstract Impaired wound healing is one of the severe complications of diabetes. Macrophages have been shown to play a vital role in wound healing. In different wound environments, macrophages are classified into two phenotypes: classically activated macrophages and alternatively activated macrophages. Dysregulation of macrophage phenotypes leads to severely impaired wound healing in diabetes. Particularly, uncontrolled inflammation and abnormal macrophage phenotype are important reasons hindering the closure of diabetic wounds. This article reviews the functions of macrophages at various stages of wound healing, the relationship between macrophage phenotypic dysregulation and diabetic wound healing and the mechanism of macrophage polarization in diabetic wound healing. New therapeutic drugs targeting phagocyte polarization to promote the healing of diabetic wounds might provide a new strategy for treating chronic diabetic wound healing.

Funder

China Scholarship Council

Outstanding Young Scientific and Technological Talents Project of Guizhou Province

Guizhou Provincial Natural Science Foundation

National Natural Science Foundation of China

Publisher

Oxford University Press (OUP)

Subject

Critical Care and Intensive Care Medicine,Dermatology,Biomedical Engineering,Emergency Medicine,Immunology and Allergy,Surgery

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