InterPro in 2022

Author:

Paysan-Lafosse Typhaine1ORCID,Blum Matthias1ORCID,Chuguransky Sara1ORCID,Grego Tiago1ORCID,Pinto Beatriz Lázaro1ORCID,Salazar Gustavo A1ORCID,Bileschi Maxwell L2ORCID,Bork Peer345ORCID,Bridge Alan6ORCID,Colwell Lucy27ORCID,Gough Julian8ORCID,Haft Daniel H9ORCID,Letunić Ivica10ORCID,Marchler-Bauer Aron9ORCID,Mi Huaiyu11ORCID,Natale Darren A12ORCID,Orengo Christine A13ORCID,Pandurangan Arun P814ORCID,Rivoire Catherine6ORCID,Sigrist Christian J A6ORCID,Sillitoe Ian13ORCID,Thanki Narmada9ORCID,Thomas Paul D11ORCID,Tosatto Silvio C E15ORCID,Wu Cathy H1216ORCID,Bateman Alex1ORCID

Affiliation:

1. European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI) , Wellcome Genome Campus, Hinxton,  Cambridgeshire  CB10 1SD, UK

2. Google Research, Brain team , Cambridge ,  MA ,  USA

3. European Molecular Biology Laboratory, Structural and Computational Biology Unit , Meyerhofstraße 1, 69117 Heidelberg , Germany

4. Yonsei Frontier Lab (YFL), Yonsei University , 03722 Seoul, South Korea

5. Department of Bioinformatics, Biocenter, University of Würzburg , 97074 Würzburg, Germany

6. Swiss-Prot Group, Swiss Institute of Bioinformatics , CMU, 1 rue Michel Servet, CH-1211, Geneva  4, Switzerland

7. Department of Chemistry, University of Cambridge ,  Cambridge , UK

8. Medical Research Council Laboratory of Molecular Biology, Cambridge Biomedical Campus , Francis Crick Ave, Trumpington, Cambridge CB2 0QH, UK

9. National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health , 8600 Rockville Pike, Bethesda , MD 20894 , USA

10. Biobyte Solutions GmbH , Bothestr 142, 69126 Heidelberg , Germany

11. Division of Bioinformatics, Department of Preventive Medicine, University of Southern California , Los Angeles , CA 90033, USA

12. Protein Information Resource, Georgetown University Medical Center , Washington , DC  20007 , USA

13. Department of Structural and Molecular Biology, University College London , Gower St, Bloomsbury, London WC1E 6BT, UK

14. Department of Biochemistry , Sanger Building, University of Cambridge, Cambridge , UK

15. Department of Biomedical Sciences, University of Padua , via U. Bassi 58/b, 35131 Padua , Italy

16. Center for Bioinformatics and Computational Biology and Protein Information Resource, University of Delaware , Newark, DE 19711 , USA

Abstract

Abstract The InterPro database (https://www.ebi.ac.uk/interpro/) provides an integrative classification of protein sequences into families, and identifies functionally important domains and conserved sites. Here, we report recent developments with InterPro (version 90.0) and its associated software, including updates to data content and to the website. These developments extend and enrich the information provided by InterPro, and provide a more user friendly access to the data. Additionally, we have worked on adding Pfam website features to the InterPro website, as the Pfam website will be retired in late 2022. We also show that InterPro's sequence coverage has kept pace with the growth of UniProtKB. Moreover, we report the development of a card game as a method of engaging the non-scientific community. Finally, we discuss the benefits and challenges brought by the use of artificial intelligence for protein structure prediction.

Funder

Wellcome Trust

Biotechnology and Biological Sciences Research Council

National Institutes of Health

National Human Genome Research Institute

National Science Foundation, Division of Biological Infrastructure

ELIXIR

Open Targets

European Molecular Biology Laboratory core funds

Wellcome Genome Campus

National Center for Biotechnology Information of the National Library of Medicine, National Institutes of Health

German Network for Bioinformatics Infrastructure

Swiss Institute of Bioinformatics

Swiss node of ELIXIR

State Secretariat for Education, Research and Innovation

Publisher

Oxford University Press (OUP)

Subject

Genetics

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