Affiliation:
1. Center for Genomics and Systems Biology, New York University , New York, NY 10003
2. Center for Genomics and Systems Biology, New York University Abu Dhabi , Abu Dhabi , United Arab Emirates
Abstract
Abstract
Deleterious genetic variation is maintained in populations at low frequencies. Under a model of stabilizing selection, rare (and presumably deleterious) genetic variants are associated with increase or decrease in gene expression from some intermediate optimum. We investigate this phenomenon in a population of largely Oryza sativa ssp. indica rice landraces under normal unstressed wet and stressful drought field conditions. We include single nucleotide polymorphisms, insertion/deletion mutations, and structural variants in our analysis and find a stronger association between rare variants and gene expression outliers under the stress condition. We also show an association of the strength of this rare variant effect with linkage, gene expression levels, network connectivity, local recombination rate, and fitness consequence scores, consistent with the stabilizing selection model of gene expression.
Funder
US National Science Foundation Plant Genome Research Program
Zegar Family Foundation,
NYU Abu Dhabi Research Institute
Publisher
Oxford University Press (OUP)
Subject
Genetics,Molecular Biology,Ecology, Evolution, Behavior and Systematics
Cited by
5 articles.
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