Affiliation:
1. Student Research Committee, Ahvaz Jundishapur University of Medical Sciences , Ahvaz, 6135715794, Iran
2. Department of Public Health, Sirjan School of Medical Sciences , Sirjan, 7816916338, Iran
3. Student Research Committee, Sirjan School of Medical Sciences , Sirjan, 7816916338, Iran
Abstract
Abstract
Context
Hesperidin is a naturally occurring bioactive compound that may influence cardiometabolic markers, but the existing evidence is inconclusive.
Objective
This study aims to further investigate the effects of hesperidin supplementation on cardiometabolic markers in adults.
Data Sources
A comprehensive search was conducted up to August 2023, utilizing relevant key words in databases such as PubMed, Scopus, Embase, and the Cochrane Central Register of Controlled Trials, focusing on randomized controlled trials (RCTs).
Data Extraction
RCTs that examined the impact of hesperidin on fasting blood sugar (FBS), insulin, quantitative insulin-sensitivity check index (QUICKI), homeostatic model assessment of insulin resistance (HOMA-IR), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), systolic blood pressure (SBP), diastolic blood pressure (DBP), tumor necrosis factor-alpha (TNF-α), and high-sensitivity C-reactive protein (hs-CRP) were selected independently by 2 authors. The GRADE assessment was used to ascertain the certainty of the evidence. Results were pooled using a random-effects model as weighted mean differences and 95% CIs.
Data Analysis
The results of this study demonstrate that hesperidin supplementation had a significant impact on reducing FBS, TG, TC, LDL-C, SBP, and TNF-α. However, there was no significant effect observed on insulin, HOMA-IR, QUICKI, HDL-C, DBP, and hs-CRP. The study's subgroup analyses also revealed that interventions lasting more than 12 weeks were effective in reducing FBS, TG, TC, and LDL-C. Moreover, hesperidin dosage exceeding 500 mg/day showed significance in reducing FBS, TC, and LDL-C levels.
Conclusion
In conclusion, this research suggests that hesperidin can be consumed as an effective dietary approach to enhance cardiometabolic markers.
Systematic Review Registration
PROSPERO registration no. CRD42022325775.
Publisher
Oxford University Press (OUP)
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