Affiliation:
1. Graduate School of Clinical Pharmacy, CHA University, Pocheon, Republic of Korea
2. College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea
3. College of Pharmacy, Korea University, Seoul, Republic of Korea
Abstract
AbstractContextKrill oil is a good source of n-3 phospholipids and has greater bioavailability than fish oil, which contains n-3 triglycerides. However, it is unclear whether krill oil affects circulating lipid concentrations more beneficially than fish oil.ObjectiveA network meta-analysis was conducted to compare the lipid-modifying effects of krill oil and fish oil.Data SourcesPubMed and Embase databases were searched.Study SelectionA total of 64 randomized controlled trials that determined the lipid-modifying effects of krill oil or fish oil were selected.Data ExtractionThe MetaXL program was used for meta-analysis. A subgroup analysis and a network meta-regression were conducted to investigate the dose-response effect of the n-3 fatty acid content of fish oil and krill oil.ResultsKrill oil was associated with significantly lower triglyceride levels than control supplements (weighted mean difference [WMD] −23.26 [95%CI, −38.84 to −7.69]). However, the net differences in triglycerides (WMD −4.07 [95%CI, −15.22 to 7.08]), low-density lipoprotein cholesterol (WMD 3.01 [95%CI, −5.49 to 11.51]), high-density lipoprotein cholesterol (WMD 1.37 [95%CI, −3.73 to 6.48]), and total cholesterol (WMD 1.69 [95%CI, −6.62 to 10.01]) were not significantly different between the krill oil and fish oil groups. One gram of n-3 fatty acids contained in fish oil and krill oil lowered median triglycerides by 8.971 mg/dL (95% credible interval [CrI], 2.27 to 14.04) and 9.838 mg/dL (95%CrI, 0.72 to 19.40), respectively.ConclusionsThe lipid-modifying effects of krill oil and fish oil do not differ. The reduction in triglycerides depends on the dose of n-3 fatty acids consumed.
Publisher
Oxford University Press (OUP)
Subject
Nutrition and Dietetics,Medicine (miscellaneous)
Cited by
11 articles.
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