Fatal Puumala Hantavirus Disease: Involvement of Complement Activation and Vascular Leakage in the Pathobiology-Reference-Cited by-同舟云学术

Fatal Puumala Hantavirus Disease: Involvement of Complement Activation and Vascular Leakage in the Pathobiology

Published:2017 Issue:4 Volume:4 Page:
ISSN:2328-8957
Container-title:Open Forum Infectious Diseases
language:en
Short-container-title:

Author:

Sironen Tarja¹,Sane Jussi¹,Lokki Marja-Liisa¹,Meri Seppo¹,Andersson Leif C¹,Hautala Timo²,Kauma Heikki²,Vuorinen Sakari³,Rasmuson Johan⁴,Evander Magnus⁵,Ahlm Clas⁴,Vaheri Antti¹

Affiliation:

1. Medicum, University of Helsinki, Helsinki, Finland

2. Department of Internal Medicine, Oulu University Hospital, Oulu, Finland

3. Etelä-Savo Hospital District, Mikkeli, Finland

4. Department of Clinical Microbiology, Infectious Diseases, Umeå University, Umeå, Sweden

5. Department of Clinical Microbiology, Virology, Umeå University, Umeå, Sweden

Abstract

Abstract The case-fatality rate of hantavirus disease depends strongly on the causative hantavirus, ranging from 0.1% to 40%. However, the pathogenesis is not fully understood, and at present no licensed therapies exist. We describe fatal cases caused by Puumala hantavirus indicating involvement of complement activation and vascular leakage.

Funder

Sigrid Jusélius Foundation

The Swedish Foundation for Strategic Research

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

Link

http://academic.oup.com/ofid/article-pdf/4/4/ofx229/33623980/ofx229.pdf

Reference15 articles.

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