Author:
Gu Yeqing,Meng Ge,Zhang Qing,Liu Li,Wu Hongmei,Zhang Shunming,Wang Yawen,Zhang Tingjing,Wang Xuena,Sun Shaomei,Wang Xing,Jia Qiyu,Song Kun,Liu Qiang,Niu Kaijun
Abstract
Abstract
Background
Previous studies have posited that an association exists between thyroid function and the heart and vasculature. It remains unclear, however, whether longitudinal trends in thyroid function contribute to the development of atherosclerosis. We conducted a cohort study to examine the association of longitudinal trends in thyroid function with incident carotid atherosclerosis (CA) in middle-aged and older euthyroid subjects.
Methods
This cohort study’s participants were recruited from the Tianjin Chronic Low-grade Systemic Inflammation and Health Cohort Study in Tianjin, China. Free triiodothyronine (FT3), thyroxine (FT4) and thyroid-stimulating hormone (TSH) were measured using chemiluminescence immunoassay. CA was assessed using carotid ultrasonography. Thyroid function and ultrasonography were assessed yearly during follow-up. Multivariable Cox proportional hazards regression models were used to assess the association between thyroid function and incident CA.
Results
A total of 3,181 participants were enrolled in the cohort study. Within 7,762 person-years of follow-up, 944 participants developed CA, the incidence rate of CA was 122 per 1,000 person-years. The fully adjusted hazards ratios (95% confidence interval) of CA for per 1-unit increase in changes of FT3, FT4 and TSH were 1.34(1.22–1.47), 1.22(1.19–1.26) and 0.92 (0.77–1.09) (P < 0.0001, <0.0001 and = 0.32, respectively), respectively. Similar significant associations between mean levels of FT3 and FT4 and incident CA were observed. However, baseline thyroid function was not associated with incident CA.
Conclusions
These findings suggest that higher mean levels and higher values of changes in thyroid hormones were associated with a higher risk of incident CA in middle-aged and older euthyroid subjects.
Funder
National Natural Science Foundation of China
Fundamental Research Funds for the Central Universities
Study of Diet and Nutrition Assessment and Intervention Technology
National Key Research and Development Program
National Health Commission of China
Nutrition Research Foundation
Publisher
Oxford University Press (OUP)
Subject
Geriatrics and Gerontology,Aging,General Medicine
Cited by
6 articles.
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