Editor’s Highlight: Complete Attenuation of Mouse Lung Cell Proliferation and Tumorigenicity in CYP2F2 Knockout and CYP2F1 Humanized Mice Exposed to Inhaled Styrene for up to 2 Years Supports a Lack of Human Relevance-Reference-Cited by-同舟云学术

Editor’s Highlight: Complete Attenuation of Mouse Lung Cell Proliferation and Tumorigenicity in CYP2F2 Knockout and CYP2F1 Humanized Mice Exposed to Inhaled Styrene for up to 2 Years Supports a Lack of Human Relevance

Published:2017-07-13 Issue:2 Volume:159 Page:413-421
ISSN:1096-6080
Container-title:Toxicological Sciences
language:en
Short-container-title:

Author:

Cruzan George¹,Bus James S.²,Banton Marcy I.³,Sarang Satinder S.⁴,Waites Robbie⁵,Layko Debra B.⁶,Raymond James⁷,Dodd Darol⁸,Andersen Melvin E.⁹

Affiliation:

1. ToxWorks, Bridgeton, New Jersey 08302

2. Exponent, Inc., Midland, Michigan 48640

3. Lyondell Chemical Company, Houston, Texas 77010

4. Shell International, Houston, Texas 77002

5. SABIC Innovative Plastics US LLC, Mount Vernon, Indiana 47620

6. Hamner, Research Triangle Park, North Carolina 27709

7. Charles River Laboratories, Inc., Frederick, Maryland 21701

8. Charles River, Spencerville, Ohio 45887;

9. ScitoVation LLC, Research Triangle Park, North Carolina 27709-5566

Publisher

Oxford University Press (OUP)

Subject

Toxicology

Link

http://academic.oup.com/toxsci/article-pdf/159/2/413/24195043/kfx141.pdf

Reference21 articles.

1. Effects of inducers and inhibitors on the microsomal metabolism of styrene to styrene oxide in mice;Carlson;J. Toxicol. Environ. Health,1997

2. Comparison of the susceptibility of wild-type and CYP2E1 knockout mice to the hepatotoxic and penumotoxic effects of styrene and styrene oxide;Carlson;Toxicol. Lett,2004

3. Cancer mortality of workers exposed to styrene in the U.S. reinforced plastics and composites industry;Collins;Epidemiology,2013

4. Styrene respiratory tract toxicity and mouse lung tumors are mediated by CYP2F-generated metabolites;Cruzan;Regul. Toxicol. Pharmacol,2002

5. Ring-oxidized metabolites of styrene contribute to styrene-induced Clara-cell toxicity in mice;Cruzan;J. Toxicol. Environ. Health A,2005

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