1. Department of Physiology, Federal University of Paraná, Curitiba, PR 81531-980, Brazil
2. Department of Animal Morphology and Physiology, Federal Rural University of Pernambuco, Recife, PE 52171900, Brazil
3. Department of Morphology and Genetics, Federal University of Sao Paulo, Sao Paulo, SP 04023-900, Brazil
4. Natural Products Department, Institute of Pharmaceutical Technology - Farmanguinhos, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, RJ 21040-900, Brazil