A 3D Human Airway Model Enables Prediction of Respiratory Toxicity of Inhaled Drugs In Vitro

Author:

Balogh Sivars Kinga1,Sivars Ulf2,Hornberg Ellinor2,Zhang Hui3,Brändén Lena2,Bonfante Rosy4,Huang Song4,Constant Samuel4,Robinson Ian5,Betts Catherine J3,Åberg Per M5

Affiliation:

1. Discovery Safety, Drug Safety and Metabolism

2. Respiratory, Inflammation and Autoimmunity

3. Pathology, Drug Safety and Metabolism

4. Epithelix Sàrl, CH-1228 Geneva, Switzerland

5. Regulatory Safety, Drug Safety and Metabolism

Publisher

Oxford University Press (OUP)

Subject

Toxicology

Reference30 articles.

1. Predicting toxicities in humans by nonclinical safety testing: An update with particular reference to anticancer compounds;Ahuja;Drug Discov. Today,2017

2. Clinical expert panel on monitoring potential lung toxicity of inhaled oligonucleotides: Consensus points and recommendations;Alton;Nucleic. Acid Ther,2012

3. An in vitro approach to assess the toxicity of inhaled tobacco smoke components: Nicotine, cadmium, formaldehyde and urethane;Balharry;Toxicology,2008

4. Evaluating the toxicity of cigarette whole smoke solutions in an air-liquid-interface human in vitro airway tissue model;Cao;Toxicol. Sci,2017

5. Addition to inhaled corticosteroids of long-acting beta2-agonists versus anti-leukotrienes for chronic asthma;Chauhan;Cochrane Database Syst. Rev,2014

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