Deep grey matter injury in multiple sclerosis: a NAIMS consensus statement

Author:

Ontaneda Daniel1ORCID,Raza Praneeta C1,Mahajan Kedar R1ORCID,Arnold Douglas L2,Dwyer Michael G3ORCID,Gauthier Susan A4ORCID,Greve Douglas N56,Harrison Daniel M7,Henry Roland G89,Li David K B10,Mainero Caterina56,Moore Wayne11,Narayanan Sridar2,Oh Jiwon12,Patel Raihaan1314,Pelletier Daniel15,Rauscher Alexander16,Rooney William D17,Sicotte Nancy L18,Tam Roger1019,Reich Daniel S20ORCID,Azevedo Christina J15,

Affiliation:

1. Cleveland Clinic Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland, OH 44195, USA

2. McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada

3. Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo, The State University of New York, Buffalo, NY 14214, USA

4. Department of Neurology, Weill Cornell Medicine, New York, NY 10021, USA

5. Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA 02129, USA

6. Department of Radiology, Harvard Medical School, Boston, MA 02129, USA

7. Department of Neurology, University of Maryland School of Medicine, Baltimore, MD 21201, USA

8. Department of Neurology, Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94143, USA

9. The UC San Francisco and Berkeley Bioengineering Graduate Group, University of California San Francisco, San Francisco, CA 94143, USA

10. Department of Radiology and Medicine (Neurology), University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada

11. Department of Pathology and Laboratory Medicine, and International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada

12. Division of Neurology, St. Michael’s Hospital, University of Toronto, Toronto, Ontario M5B 1W8, Canada

13. Cerebral Imaging Centre, Douglas Mental Health University Institute, Verdun, Quebec H4H 1R3, Canada

14. Department of Biological and Biomedical Engineering, McGill University, Montreal, Quebec H3A 2B4, Canada

15. Department of Neurology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA

16. Physics and Astronomy, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada

17. Advanced Imaging Research Center, Oregon Health and Science University, Portland, OR 97239, USA

18. Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA

19. Biomedical Engineering, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada

20. Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20824, USA

Abstract

Abstract Although multiple sclerosis has traditionally been considered a white matter disease, extensive research documents the presence and importance of grey matter injury including cortical and deep regions. The deep grey matter exhibits a broad range of pathology and is uniquely suited to study the mechanisms and clinical relevance of tissue injury in multiple sclerosis using magnetic resonance techniques. Deep grey matter injury has been associated with clinical and cognitive disability. Recently, MRI characterization of deep grey matter properties, such as thalamic volume, have been tested as potential clinical trial end points associated with neurodegenerative aspects of multiple sclerosis. Given this emerging area of interest and its potential clinical trial relevance, the North American Imaging in Multiple Sclerosis (NAIMS) Cooperative held a workshop and reached consensus on imaging topics related to deep grey matter. Herein, we review current knowledge regarding deep grey matter injury in multiple sclerosis from an imaging perspective, including insights from histopathology, image acquisition and post-processing for deep grey matter. We discuss the clinical relevance of deep grey matter injury and specific regions of interest within the deep grey matter. We highlight unanswered questions and propose future directions, with the aim of focusing research priorities towards better methods, analysis, and interpretation of results.

Funder

Race to Erase MS Foundation

NAIMS

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Neurology (clinical)

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