Progression of regional grey matter atrophy in multiple sclerosis

Author:

Eshaghi Arman12ORCID,Marinescu Razvan V2,Young Alexandra L2,Firth Nicholas C2,Prados Ferran3ORCID,Jorge Cardoso M3,Tur Carmen1,De Angelis Floriana1,Cawley Niamh1,Brownlee Wallace J1,De Stefano Nicola4,Laura Stromillo M4,Battaglini Marco4,Ruggieri Serena56,Gasperini Claudio5,Filippi Massimo7,Rocca Maria A7,Rovira Alex8,Sastre-Garriga Jaume9,Geurts Jeroen J G10,Vrenken Hugo11,Wottschel Viktor11,Leurs Cyra E12,Uitdehaag Bernard12,Pirpamer Lukas13,Enzinger Christian1314,Ourselin Sebastien315,Gandini Wheeler-Kingshott Claudia A11617,Chard Declan115,Thompson Alan J1,Barkhof Frederik131511,Alexander Daniel C2,Ciccarelli Olga115

Affiliation:

1. Queen Square Multiple Sclerosis Centre, UCL Institute of Neurology, Faculty of Brain Sciences, University College London, London, UK

2. Centre for Medical Image Computing (CMIC), Department of Computer Science, University College London, UK

3. Translational Imaging Group, Centre for Medical Image Computing (CMIC), Department of Medical Physics and Bioengineering, University College London, London, UK

4. Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy

5. Department of Neurosciences, S Camillo Forlanini Hospital, Rome, Italy

6. Department of Neurology and Psychiatry, University of Rome Sapienza, Rome, Italy

7. Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy

8. MR Unit and Section of Neuroradiology, Department of Radiology, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain

9. Department of Neurology/Neuroimmunology, Multiple Sclerosis Centre of Catalonia (CEMCAT), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain

10. Department of Anatomy and Neurosciences, VUmc MS Center, Neuroscience Amsterdam, VU University Medical Center, Amsterdam, The Netherlands

11. Department of Radiology and Nuclear Medicine, MS Center Amsterdam, Amsterdam, The Netherlands

12. Department of Neurology, MS Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands

13. Department of Neurology, Medical University of Graz, Graz, Austria

14. Division of Neuroradiology, Department of Radiology, Medical University of Graz, Graz, Austria

15. National Institute for Health Research (NIHR), University College London Hospitals (UCLH) Biomedical Research Centre (BRC), London, UK

16. Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy

17. Brain MRI 3T Research Centre, IRCCS Mondino Foundation, Pavia, Italy

Funder

EPSRC

Publisher

Oxford University Press (OUP)

Subject

Neurology (clinical)

Reference45 articles.

1. Atrophy mainly affects the limbic system and the deep grey matter at the first stage of multiple sclerosis;Audoin;J Neurol Neurosurg Psychiatry,2010

2. Evaluating and reducing the impact of white matter lesions on brain volume measurements;Battaglini;Hum Brain Mapp,2012

3. Atrophy and structural variability of the upper cervical cord in early multiple sclerosis;Biberacher;Mult Scler,2015

4. White and gray matter damage in primary progressive MS: the chicken or the egg?;Bodini;Neurology,2016

5. Distributed changes in default-mode resting-state connectivity in multiple sclerosis;Bonavita;Mult Scler,2011

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