Organ-quarantined therapy: in situ normothermic machine perfusion of the renal allograft in a patient with a kidney transplant and an abdominal aortic aneurysm

Abstract

To prevent kidney ischemia injury from common iliac artery blockage during surgical resection of AAA, we developed an in situ closed NMP system to specifically maintain the physiological support of the renal allograft, and we called this therapeutic method “organ-quarantined therapy (OQT)”. This OQT method runs a novel idea and platform for organ therapy that enables targeted treatment of specific organs while minimizing systemic adverse effects.This approach has the potential to significantly reduce overall drug dosage and minimize systemic toxicity, making OQT a safe, efficient, and low-toxicity option.