1. Department of Pharmaceutical Sciences, State University of Ponta Grossa , Av. Carlos Cavalcanti, 4748, Uvaranas, Ponta Grossa, Paraná 84.030-900 , Brazil
2. Department of Pharmacy, Federal University of Parana , Av. Prefeito Lothário Meissner, 623, Jardim Botânico, Curitiba, Parana 80210-170 , Brazil