Structure guided fluorescence labeling reveals a two-step binding mechanism of neomycin to its RNA aptamer

Author:

Gustmann Henrik1ORCID,Segler Anna-Lena J2,Gophane Dnyaneshwar B2,Reuss Andreas J1,Grünewald Christian3,Braun Markus1,Weigand Julia E4ORCID,Sigurdsson Snorri Th2ORCID,Wachtveitl Josef1ORCID

Affiliation:

1. Institute of Physical and Theoretical Chemistry, Goethe-University Frankfurt am Main, Max-von-Laue-Strasse 7, 60438 Frankfurt, Germany

2. Science Institute, University of Iceland, Dunhaga 3, 107 Reykjavik, Iceland

3. Institute for Organic Chemistry and Chemical Biology, Goethe-University Frankfurt am Main, Max-von-Laue-Strasse 7, 60438 Frankfurt, Germany

4. Department of Biology, Technical University Darmstadt, Schnittspahnstraße 10, 64287 Darmstadt, Germany

Funder

Deutsche Forschungsgemeinschaft

Publisher

Oxford University Press (OUP)

Subject

Genetics

Reference73 articles.

1. Enzymatic cleavage of RNA by RNA (Nobel lecture);Altman;Angew. Chem. Int. Ed. Engl.,1990

2. Self-splicing and enzymatic activity of an intervening sequence RNA from Tetrahymena (Nobel Lecture);Cech;Biosci. Rep.,1990

3. Origin of life: the RNA world;Gilbert;Nature,1986

4. The origins of the RNA world;Robertson;Cold Spring Harb. Perspect. Biol.,2012

5. The rise of regulatory RNA;Morris;Nat. Rev. Genet.,2014

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