Treatment of axial spondyloarthritis with biologic and targeted synthetic DMARDs: British Society for Rheumatology guideline scope

Author:

Zhao Sizheng Steven1ORCID,Harrison Stephanie R23,Chan Antoni4ORCID,Clarke Nick5,Davis Charlotte6,Eddison Joe5,Gregory William J78ORCID,Jones Gareth T9ORCID,Marzo-Ortega Helena23ORCID,Murphy Daniel J10,Sandhu Virinderjit11,Sengupta Raj12,Siebert Stefan13ORCID,Thompson Ben14,Webb Dale15,Yates Max1617,Gaffney Karl17ORCID

Affiliation:

1. Centre for Epidemiology Versus Arthritis, Division of Musculoskeletal and Dermatological Science, School of Biological Sciences, Faculty of Biological Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre , Manchester, UK

2. Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds , Leeds, UK

3. NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals Trust , Leeds, UK

4. Department of Rheumatology, Royal Berkshire NHS Foundation Trust , Reading, UK

5. Patient Expert

6. Department of Rheumatology, Leeds Teaching Hospitals Trust , UK

7. Rheumatology Department, Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust , Greater Manchester, UK

8. Faculty of Health and Education, Manchester Metropolitan University , Manchester, UK

9. Aberdeen Centre for Arthritis and Musculoskeletal Health (Epidemiology Group), University of Aberdeen , Aberdeen, UK

10. Department of Rheumatology, Honiton Surgery, Royal Devon & Exeter Hospital , Exeter, UK

11. Department of Rheumatology, St George’s University Hospitals NHS Foundation Trust , London, UK

12. Royal National Hospital for Rheumatic Diseases, Royal United Hospitals , Bath, UK

13. School of Infection and Immunity, University of Glasgow , Glasgow, UK

14. Rheumatology Department, The Newcastle-upon-Tyne Hospitals NHS Foundation Trust , Newcastle-upon-Tyne, UK

15. National Axial Spondyloarthritis Society (NASS) , London, UK

16. Centre for Epidemiology, Norwich Medical School, University of East Anglia , Norwich, UK

17. Rheumatology Department, Norfolk & Norwich University Hospitals NHS Foundation Trust , Norwich, UK

Abstract

Abstract Pharmacological management has advanced considerably since the 2015 British Society for Rheumatology axial spondyloarthritis (axSpA) guideline to incorporate new classes of biologic DMARDs (bDMARDs, including biosimilars), targeted synthetic DMARDs (tsDMARDs) and treatment strategies such as drug tapering. The aim of this guideline is to provide an evidence-based update on pharmacological management of adults with axSpA (including AS and non-radiographic axSpA) using b/tsDMARDs. This guideline is aimed at health-care professionals in the UK who care directly for people with axSpA, including rheumatologists, rheumatology specialist nurses, allied health professionals, rheumatology specialty trainees and pharmacists; people living with axSpA; and other stakeholders, such as patient organizations and charities.

Funder

British Society for Rheumatology

Publisher

Oxford University Press (OUP)

Subject

Rheumatology

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